Table 8 Patient characteristics s in Low and High PNI groups according to liver fictional preserve
LHL15 ≥ 0.9 | LHL15 < 0.9 | |||||
|---|---|---|---|---|---|---|
Variables | Low PNI (n = 7) | High PNI (n = 146) | p value | Low PNI (n = 10) | High PNI (n = 26) | p value |
Age (years) | 72 (57–77) | 70 (41–85) | n.s | 65 (47–81) | 68 (47–83) | n.s |
Sex (male / female) | 3 / 4 | 122 / 24 | 0.02 | 8/2 | 20/6 | n.s |
BMI | 21.7 (16.8–26.3) | 22.1 (14.0–32.5) | n.s | 24.6 (15.6–29.6) | 22.1 (13.2–31.5) | n.s |
Lymphocyte count (/mm3) | 710 (530–1290) | 1455 (350–2930) | 0.001 | 800 (320–2260) | 1500 (650–2950) | 0.002 |
Neutrophil count (/mm3) | 3190 (910–8780) | 3160 (1020–8680) | n.s | 2420 (1140–7170) | 2225 (820–3610) | n.s |
Platelet count (103/µl) | 23.6 (6.6–37.9) | 18.9 (4.8–219.0) | n.s | 12.2 (4.4–28.9) | 14.1 (4.1–156.0) | n.s |
Albumin (g/dl) | 3.1 (2.3–3.3) | 3.9 (2.7–5.3) | < 0.001 | 2.8 (2.3–3.4) | 3.7 (3.0–4.7) | < 0.001 |
Total bilirubin (mg/dl) | 0.5 (0.4–1.5) | 0.6 (0.2–1.5) | n.s | 0.85 (0.4–1.6) | 0.6 (0.3–2.5) | n.s |
PT-INR | 1.16 (0.87–1.30) | 1.04 (0.88–1.28) | 0.018 | 1.16 (1.0–1.41) | 1.10 (0.93–1.34) | n.s |
Child–Pugh A/B/C | 6 / 1 / 0 | 143 / 3 / 0 | n.s | 5 / 5 / 0 | 2 / 24 / 0 | n.s |
AFP (ng/ml) | 40 (2–33,430) | 9 (1–253,875) | n.s | 122 (9–60,105) | 29 (4–88,940) | n.s |
DCP (mAU/ml) | 1501 (28–85,330) | 88 (1–286,400) | n.s | 260 (14–29,182) | 237 (10–174,400) | n.s |
ICG R15 (%) | 13.5 (6.3–28.8) | 11.8 (0.3–76.3) | n.s | 31.7 (9.9–49.9) | 18.3 (7.0–42.0) | n.s |
LHL15 | 0.935 (0.904–0.963) | 0.940 (0.90–0.987) | n.s | 0.853 (0.679–0.885) | 0.876 (0.758–0.898) | 0.04 |
Tumor size (cm) | 7.0 (2.0–13.0) | 4.0 (0.5–24.0) | n.s | 3.0 (1.1–15.0) | 3.5 (0.7–20.0) | n.s |
Multiple tumor | 2 (29%) | 38 (26%) | n.s | 5 (50%) | 4 (15.4%) | n.s |
BCLC stage 0/A/B/C | 0 / 6 / 0 / 1 | 13 / 91 / 31 / 11 | n.s | 0 / 7 / 3 / 0 | 4 / 17 / 4 / 1 | n.s |
Within Milan criteria | 2 (29%) | 78 (53%) | n.s | 7 (70%) | 20 (76.9%) | n.s |
PNI | 34.7(26.6–36.9) | 46.2 (37.4–60.0) | < 0.001 | 33.6 (26.0–36.5) | 44.3 (37.3–54.8) | < 0.001 |
NLR | 4.49 (0.85–8.58) | 2.10 (0.52–12.8) | n.s | 3.20 (1.07–14.16) | 1.54 (0.56–3.14) | 0.001 |
PLR | 231 (110–486) | 138 (33–1685) | 0.022 | 189 (49–350) | 91 (35–1033) | n.s |
ALBI grade 1 / 2 / 3 | 0 / 6 / 1 | 74 / 72 / 0 | 0.001 | 0 / 6 / 4 | 11 / 15 / 0 | 0.001 |
Underlying liver disease | ||||||
NBNC / HBV / HCV | 1 / 2 / 4 | 76 / 21 / 49 | n.s | 2 / 0 / 8 | 6 / 3 / 17 | n.s |