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Table 8 Patient characteristics s in Low and High PNI groups according to liver fictional preserve

From: Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function

  LHL15 ≥ 0.9   LHL15 < 0.9  
Variables Low PNI (n = 7) High PNI (n = 146) p value Low PNI (n = 10) High PNI (n = 26) p value
Age (years) 72 (57–77) 70 (41–85) n.s 65 (47–81) 68 (47–83) n.s
Sex (male / female) 3 / 4 122 / 24 0.02 8/2 20/6 n.s
BMI 21.7 (16.8–26.3) 22.1 (14.0–32.5) n.s 24.6 (15.6–29.6) 22.1 (13.2–31.5) n.s
Lymphocyte count (/mm3) 710 (530–1290) 1455 (350–2930) 0.001 800 (320–2260) 1500 (650–2950) 0.002
Neutrophil count (/mm3) 3190 (910–8780) 3160 (1020–8680) n.s 2420 (1140–7170) 2225 (820–3610) n.s
Platelet count (103/µl) 23.6 (6.6–37.9) 18.9 (4.8–219.0) n.s 12.2 (4.4–28.9) 14.1 (4.1–156.0) n.s
Albumin (g/dl) 3.1 (2.3–3.3) 3.9 (2.7–5.3)  < 0.001 2.8 (2.3–3.4) 3.7 (3.0–4.7)  < 0.001
Total bilirubin (mg/dl) 0.5 (0.4–1.5) 0.6 (0.2–1.5) n.s 0.85 (0.4–1.6) 0.6 (0.3–2.5) n.s
PT-INR 1.16 (0.87–1.30) 1.04 (0.88–1.28) 0.018 1.16 (1.0–1.41) 1.10 (0.93–1.34) n.s
Child–Pugh A/B/C 6 / 1 / 0 143 / 3 / 0 n.s 5 / 5 / 0 2 / 24 / 0 n.s
AFP (ng/ml) 40 (2–33,430) 9 (1–253,875) n.s 122 (9–60,105) 29 (4–88,940) n.s
DCP (mAU/ml) 1501 (28–85,330) 88 (1–286,400) n.s 260 (14–29,182) 237 (10–174,400) n.s
ICG R15 (%) 13.5 (6.3–28.8) 11.8 (0.3–76.3) n.s 31.7 (9.9–49.9) 18.3 (7.0–42.0) n.s
LHL15 0.935 (0.904–0.963) 0.940 (0.90–0.987) n.s 0.853 (0.679–0.885) 0.876 (0.758–0.898) 0.04
Tumor size (cm) 7.0 (2.0–13.0) 4.0 (0.5–24.0) n.s 3.0 (1.1–15.0) 3.5 (0.7–20.0) n.s
Multiple tumor 2 (29%) 38 (26%) n.s 5 (50%) 4 (15.4%) n.s
BCLC stage 0/A/B/C 0 / 6 / 0 / 1 13 / 91 / 31 / 11 n.s 0 / 7 / 3 / 0 4 / 17 / 4 / 1 n.s
Within Milan criteria 2 (29%) 78 (53%) n.s 7 (70%) 20 (76.9%) n.s
PNI 34.7(26.6–36.9) 46.2 (37.4–60.0)  < 0.001 33.6 (26.0–36.5) 44.3 (37.3–54.8)  < 0.001
NLR 4.49 (0.85–8.58) 2.10 (0.52–12.8) n.s 3.20 (1.07–14.16) 1.54 (0.56–3.14) 0.001
PLR 231 (110–486) 138 (33–1685) 0.022 189 (49–350) 91 (35–1033) n.s
ALBI grade 1 / 2 / 3 0 / 6 / 1 74 / 72 / 0 0.001 0 / 6 / 4 11 / 15 / 0 0.001
Underlying liver disease       
 NBNC / HBV / HCV 1 / 2 / 4 76 / 21 / 49 n.s 2 / 0 / 8 6 / 3 / 17 n.s
  1. Differences were considered significant at p < 0.05, shown as italic values
  2. BMI body mass index, PNI prognostic nutritional index, PT-INR prothrombin time-international normalized ratio, AFP alpha fetoprotein, DCP des-γ-carboxyprothrombin, ICGR15 indocyanine green retention rate at 15 min, LHL15 GSA uptake ratio of the liver to the liver plus heart at 15 min, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, ALBI grade Albumin-Bilirubin grade, NBNC Non-B non-C, HBV hepatits B, HCV hepatitis C