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Table 4 Comparison of patient characteristics between Low and High PNI groups

From: Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function

PNI median Low PNI
(PNI < 37: n = 17)
33.6 (26.0–36.9)
High PNI
(PNI ≥ 37: n = 172)
45.9 (37.3–60.0)
p value
Age 68 (47–81) 70 (41–85) n.s
Sex (male / female) 11/6 142/30 n.s
BMI 23.2 (15.6–29.6) 22.1 (13.2–32.5) n.s
Lymphocyte count (/mm3) 710 (320–2260) 1480 (350–2950)  < 0.001
Neutrophil count (/mm3) 2420 (910–8780) 3030 (820–8680) n.s
Albumin (g/dl) 2.9 (2.3–3.4) 3.8 (2.7–5.3)  < 0.001
Total bilirubin (mg/dl) 0.6 (0.4–1.6) 0.6 (0.2–2.5) n.s
Platelet count (103/µl) 13.4 (4.4–37.9) 18.6 (4.1–219.0) n.s
PT-INR 1.16 (0.87–1.41) 1.05 (0.88–1.34)  < 0.001
Child–Pugh A/B/C 11 / 6 / 0 167 / 5 / 0  < 0.001
ICG R15 (%) 23.9 (6.3–49.9) 12.6 (0.3–76.3) 0.007
LHL15 0.87 (0.68–0.96) 0.94 (0.76–0.99)  < 0.001
ALBI grade 1 / 2 / 3 0 / 12 / 5 85 / 87 / 0  < 0.001
NLR 3.98 (0.86–14.16) 2.00 (0.52–12.8) 0.004
PLR 223 (49–486) 134 (23–1685) n.s
Underlying liver disease    0.03
 Hepatitis B 2 (12%) 24 (14%)  
 Hepatitis C 12 (70%) 66 (38%)  
 Non-B non-C 3 (18%) 82 (48%)  
Liver pathology    n.s
 Normal liver 1 (6%) 23 (15%)  
 Chronic hepatitis 5 (29%) 72 (47%)  
 Liver cirrhosis 11 (65%) 59 (38%)  
  1. Differences were considered significant at p < 0.05, shown as italic values
  2. BMI body mass index, PNI prognostic nutritional index, ICGR15 indocyanine green retention rate at 15 min, LHL15 GSA uptake ratio of the liver to the liver plus heart at 15 min, ALBI score albumin-bilirubin score, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio