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Table 5 Factors influencing morbidity and mortality on bivariate logistic regression of patients with perforated Peptic ulcer disease in four teaching hospital in Addis Ababa, Ethiopia

From: Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study

Variable

 

Complications N (%)

N = 16

No Complications N (%)

N = 68

P-value

Death N (%)

N = 3

Discharged improved N (%)

N = 94

P-value

Sex

Male

16 (19.04)

68 (80.1)

 

3(3.6)

81(96.4)

 
 

Female

0 (0)

13(100)

0.136

0

13

0.787

Age

11–20

3 (17.6)

14 (82.4)

 

0 (0)

17(100)

 
 

21–30

4(9.8)

37 (90.2)

 

0(0)

41(100)

 
 

31–40

4 (17.4)

19 (82.6)

 

2 (8.7)

21(91.3)

 
 

41–50

1 (25)

3 (75)

 

0(0)

4 (100)

 
 

51–60

1 (16.7)

5 (83.3)

 

0 (0)

6(100)

 
 

61–70

2 (50)

2 (50)

 

1(25)

3(75)

 
 

71–80

1 (50)

1 (50)

0.08

0(0)

2 (100)

0.003

Address

AA

12 (14.6)

70(85.4)

 

3 (3.6)

79(96.4)

 
 

Outside

4 (26.7)

11(73.3)

0.391

0 (0)

15(100)

0.475

Religion

Orthodox

11(14.9)

63(85.1)

 

2 (2.7)

73 (98.3)

 
 

Muslim

4(25)

12(75)

 

1 (6.3)

15 (93.7)

 
 

Others Christians

0(0)

6(100)

0.310

0 (0)

6 (100)

0.746

History of PUD

History of PUD

13 (17.8)

60 (82.2)

 

3 (4.1)

70 (95.90

 
 

No history of PUD

3 (12.50

21(87.50

 

0 (0)

24(100)

0.337

Smoking

Yes

5 (15.6)

27(84.40)

 

0 (0)

32(100)

 
 

No

11(16.9)

54 (84.10

0.922

3 (4.6)

62 (95.4)

0.240

Alcohol

Yes

4 (16.4)

38(83.6)

 

0 (0)

44 (100)

 
 

No

10 (18.70)

43 (81.3)

0.212

  

0.126

Khat use/Catha edulis

Yes

2 (12.5)

14 (87.5)

 

1(5.9)

16 (94.1)

 
 

NO

15 (18.5)

66 (81.5)

0.141

2 (2.5)

78 (97.5)

0.323

Co-morbidity

Yes

0 (0)

3 (100)

 

1(33.3)

2 (66.70

 
  

16 (17)

78(83)

   

0.00

NSAID use

yes

1 (50)

1(50)

 

0 (0)

2 (100)

 
 

No

15 (15.8)

80 (84.2)

0.076

3 (3.2)

92(96.8)

0.809

Hx of PUD

Yes

13(17.8)

60 (82.2)

 

3 (4.1)

70 (95.9)

 
 

No

3 (12.5)

21(87.5)

0.139

0

0

 

H.Pylri infection

Present

1 (33.3)

2 (66.7)

0.647

1 (33.3)

2 (66.70

0.02

Duration at presentation

<  24 h.

4 (9)

40 (91)

 

0(0)

44 (100)

 
 

24–48 h.

5 (15.1)

28 (84.9)

 

1 (3)

32 (97)

 
 

48–72 h.

3 (27.3)

7(72.7)

 

0(0)

10 (100)

 
 

> 72 h.

4 (40)

6 (60)

0.004

2 (20)

8 (80)

0.003

WBC count

Raised

7 (15.6)

38 (84.4)

 

0 (0)

45 (100)

 
 

Normal

9 (17.3)

43 (82.7)

0.610

3 (5.8)

49 (94.2)

 

CXR finding

Free air

14 (16.7)

69 (83.3)

 

2 (2.4)

81(97.6)

 
 

Not detected

1(9.1)

10 (90.9)

 

0 (0)

11(100)

 
 

Not done

1 (33.3)

2 (66.7)

 

1 (33.3)

2 (66.7)

 

Hypotension

Yes

9 (52.9)

8 (47.1)

0.000

3 (17.6)

14 (82.4)

0.001

Perforation size

< 10 mm

7 (9.2)

69 (90.8)

 

0 (0)

79 (100)

 
 

10-20 mm

5 (41.7)

7 (59.3)

 

1 (8.3)

11(91.7)

 
 

> 20 mm

1 (50)

1 (50)

 

2 (100)

0 (0)

0.000

 

Sealed

0 (0)

4 (100)

0,046

0 (0)

1(100)

 

contamination

<  1 Lts

7 (9.7)

65 (90.3)

 

1 (1.4)

71 (98.6)

 
 

1–3 Lts

7 (33.3)

14 (66.7)

 

1 (4.8)

20 (95.2)

 
 

> 3 Lts

1 (33.3)

2 (66.7)

0.000

1 (25)

3 (75)

0.006

Procedure done

Simple closure

0 (0)

0 (0)

 

0 (0)

0 (0)

 
 

Pedicled omental

11(16.9)

54 (83.1)

 

3 (4.6)

62(95.4)

 
 

Free omental

5 (18.5)

23 (81.5)

0.399

0 (0)

27 (100)

 

Drainage left

 

15 (16.8)

74 (83.2)

 

3 (3.4)

86 (96.6)