The predictors and patterns of the early recurrence of pancreatic ductal adenocarcinoma after pancreatectomy: the influence of pre- and post- operative adjuvant therapy

Table 2 Subgroup analysis for the clinical factors affecting early recurrence in patients who received CRT preoperatively (n = 51) or upfront surgery (n = 64)

		Patients who received CRT preoperatively (n = 51)						Patients who received upfront surgery (n = 64)
		Group E (n = 11)^b	Group NE (n = 40)^c	P-value	HR	95% CI	P-value^※	Group E (n = 23)^b	Group NE (n = 41)^c	P-value	HR	95% CI	P-value^※
BMI^a	< 21.5	7 (70%)	15 (39%)	0.085
CRP^a	≧ 0.19							13 (72%)	18 (46%)	0.066
CA19–9^a	≧ 173							14 (61%)	15 (38%)	0.088
NLR^a	≧ 4.65	6 (60%)	9 (25%)	0.037				2 (20%)	1 (4%)	0.098
Lymphocyte count^a	≦ 1648							15 (94%)	25 (66%)	0.032
Postoperative CA19–9 normalization	No	6 (86%)	5 (22%)	0.002	83.36	3.32–2095.0	0.007	11 (79%)	4 (18%)	< 0.001	39.26	3.65–422.10	0.002
Postoperative ACT	No	5 (45%)	7 (18%)	0.053				13 (57%)	5 (12%)	< 0.001	15.53	2.51–96.04	0.003
Tumor size^a	≧ 3.0							16 (70%)	16 (43%)	0.047
PALN metastasis	Positive	1 (10%)	0 (0%)	0.052
LN metastasis	Positive	8 (73%)	17 (43%)	0.076
ly	Positive	9 (82%)	21 (53%)	0.080
S	Positive	10 (91%)	17 (43%)	0.004	13.08	1.25–137.46	0.032
A	Positive	2 (18%)	1 (3%)	0.050
PL	Positive	7 (64%)	13 (33%)	0.061
Resection status	R1							5 (21%)	2 (5%)	0.038	10.03	0.84–118.82	0.067

※; logistic regression analysis, Variables with P ≦ 0.10 are shown in this table
^aThe cutoff values of BMI, CRP, NLR, lymphocyte count and tumor size were set by drawing a receiver operating characteristic curve
^bRecurrence within 6 months after surgery
^cRecurrence at more than 6 months after surgery

ISSN: 1471-2482