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Table 1 Brief information of the included studies

From: Meta-analysis of studies comparing conservative treatment with antibiotics and appendectomy for acute appendicitis in the adult

First author Eriksson S Oliak D Tingstedt B Styrud J Liu K Hansson J Turhan A Vons C Hansson J Mentula P Salminen P
Year 1995 2001 2002 2006 2007 2009 2009 2011 2012 2015 2015
Journal Br J Surg Dis Colon rectum Eur J Surg World J Surg Am Surg Br J Surg Ulus Travma Acil Cerrahi Derg Lancet World J Surg Ann Surg JAMA
Region Sweden USA Sweden Sweden USA Sweden Turkey France Sweden Finland Finland
Study type Prospective controlled Retrospective Retrospective Multicentre RCT Retrospective Multicentre RCT Prospective controlled Multicentre RCT Prospective nonrandomized Single centre RCT Multicentre RCT
No. conservative group 20 88 50 128 19 202 107 120 442 30 257
No. surgery group 20 67 43 124 51 167 183 119 111 30 273
Patient type Mixed Periappendiceal abscess Periappendiceal abscess Mixed Uncomplicated Mixed Mixed Uncomplicated Mixed Periappendiceal abscess Uncomplicated
Antibiotic strategy (cefotaxime 2 g bid + tinidazole 0.8 g qd) iv 2d + (ofloxacin 0.2 g bid + tinidazole 0.5 g bid) po 8d iv administration, N/A (cephalosporin + metronidazole OR imipenem) iv + (cephalosporin + metronidazole) po (cefotaxime 2 g bid + tinidazole 0.8 g qd) iv 2d + (ofloxacin 0.2 g bid + tinidazole 0.5 g bid) po 10d iv 1-6d + po 7-14d (cefotaxime 1 g bid + metronidazole 1.5 g qd) iv 1d + (ciprofloxacin 0.5 g bid + metronidazole 0.4 g tid) po 10d (ampicillin 1 g qid + gentamicin 160 mg qd + metronidazole 0.5 g tid) iv 3d + N/A po 7d amoxicillin/clavulanic acid (3 g/d if BW < 90 kg, 4 g/d if BW > 90 kg), iv OR po (piperacillin/tazobactam 4 g tid) iv 1d + (ciprofloxacin 0.5 g + metronidazole 400 mg bid) po 9d (cefuroxime 1.5 g tid + metronidazole 0.5 g qd) iv + (cephalexin 0.5 g tid + metronidazole 0.5 g tid) po 7d (ertapenem 1 g qd) iv 3d + (levofloxacin 0.5 g qd + metronidazole 0.5 g tid) po 7d
Other conservative strategy N/A PCD selectively, if not improve in 72 h will receive appendectomy PCD (18%, 9/50) if not improve in 24 h will receive appendectomy N/A N/A N/A if not improve in 48 h will receive appendectomy if not improve in 24–48 h will receive appendectomy PCD if abscess> 3 cm N/A
Conflict of Interests Swedish Hoechst AB, Pfizer AB, Mutual Group Life Insurance Company ‘Forenade Liv’ N/A N/A Wallenius Corporation, Aventis Pharma N/A None N/A None None None Merck, Roche