Table 4 Results of univariable and multivariable regression for pancreatic cancer after surgery of CP
From: Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | |
Sex | ||||
Male | 0.811(0.219–2.997) | 0.753 | ||
Female | 1.0 | |||
Age, (yrs) | ||||
≤ 50 | 1 | 0.386 | ||
>50 | 0.561 (0.152–2.072) | |||
Time interval to surgery, (mons) | 1.005 (1.002–1.008) | 0.002 | 1.005(1.002–1.008) | 0.002 |
Etiology | 0.995 | |||
Alcoholic | 0.942(0.299–2.971) | 0.919 | ||
Idiopathic | 1 | |||
Hereditary | 0.000 | 0.985 | ||
Smoking | 0.222 | |||
past | 1.215 (0.110–13.401) | 0.874 | ||
current | 3.378 (0.730–15.642) | 0.119 | ||
never | 1 | |||
Alcohol consumption | 0.719 | |||
past | 2.761(0.238–32.048) | 0.417 | ||
current | 1.383(0.299–6.402) | 0.678 | ||
never | 1 | |||
Preoperative pain | ||||
Yes | 1.081 (0.139–8.381) | 0.941 | ||
No | 1 | |||
Preoperative steatorrhea | ||||
Yes | 1.044 (0.228–4.782) | 0.958 | ||
No | 1 | |||
Preoperative diabetes | ||||
Yes | 0.851 (0.255–2.840) | 0.793 | ||
No | 1 | |||
Operating time, min | ||||
≤ 180 | 1 | 0.803 | ||
> 180 | 1.165 (0.351–3.874) | |||
Blood loss, ml | ||||
≤ 200 | 1 | 0.390 | ||
> 200 | 1.694(0.509–5.641) | |||
Blood transfusion | ||||
Yes | 1.864(0.240–14.471) | 0.552 | ||
No | 1 | |||
Type of surgery | ||||
PD | 0.000 | 0.986 | ||
DPPHR | 6.671 (0.852–52.242) | 0.71 | ||
DP | 2.857 (0.179–45.694) | 0.458 | ||
Partington procedure | 1 | |||
Pancreatic fistula | ||||
Yes | 0.48 (0.000–7,203,834.567) | 0.752 | ||
No | 1 | |||
Hemorrhage | ||||
Yes | 0.049(0.000–71,526,595.29) | 0.779 | ||
No | 1 | |||
Biliary fistula | ||||
Yes | 0.50 (0.000–2.309E+ 26) | 0.926 | ||
No | 1 | |||
Complications (greater than grade ≥ 2) | ||||
Yes | 5.338 (0.687–41.512) | 0.109 | ||
No | 1 | |||
Hospital stay after operation, (days) | ||||
≤ 7 | 1 | |||
> 7 | 0.803 (0.252–2.556) | 0.710 | ||
Postoperative abdominal pain | ||||
Yes | 2.457 (0.792–7.619) | 0.120 | ||
No | 1 | |||
De novo pain | ||||
Yes | 0.49 (0.000–6.085E+ 10) | 0.832 | ||
No | 1 | |||
Worsening pain | 0.358 | |||
Yes | 5.606 (0.721–43.560) | 0.099 | ||
No | 1 | |||
Total postoperative endocrine insufficiency | 0.579 | |||
Yes | 2.949 (0.883–9.851) | 0.079 | ||
No | 1 | |||
De novo endocrine insufficiency | 10.672 (2.567–44.372) | 0.001 | ||
Yes | 13.106 (3.944–43.552) | 0.000 | ||
No | 1 | |||
Total postoperative exocrine insufficiency | ||||
Yes | 1.121 (0.303–4.144) | 0.864 | ||
No | 1 | |||
De novo exocrine insufficiency | ||||
Yes | 1.242 (0.159–9.681) | 0.836 | ||
No | 1 | |||
Give up smoking | ||||
Yes | 2.623 (0.790–8.714) | 0.115 | ||
No | 1 | |||
Give up drinking | ||||
Yes | 2.009 (0.637–6.340) | 0.234 | ||
No | 1 | |||