Analysis of outcomes and predictors of long-term survival following resection for retroperitoneal sarcoma

BMC Surgery

Table 2 Univariate and multivariate analysis of clinicopathologic variables associated with overall survival in 61 patients who underwent resection for primary retroperitoneal sarcoma

Variable	N (%)	5-year Overall Survival (%)	Univariate Analysis P	Multivariate Analysis*
Variable	N (%)	5-year Overall Survival (%)	Univariate Analysis P	P	Hazard Ratio (95% CI)
Sex			.572
Male	29 (48)	45
Female	32 (52)	65
BMI (Body Mass Index)			.483
< 25	28 (46)	65
≥25	33 (54)	52
Patient age at resection			.157
≥ 60 years	21 (35)	40
18–59 years	38 (62)	68
< 18 years	2 (3)	100
Tobacco use			.522
Yes	15 (25)	44
No	46 (75)	60
Tumour entity			.018	NS
Leiomyosarcoma	19 (31)	71
Liposarcoma, dedifferentiated	14 (23)	32
Liposarcoma, well-differentiated	12 (20)	79
Undifferentiated sarcoma, NOS	8 (13)	31
Liposarcoma, pleomorphic	3 (5)	39
Malignant Peripheral Nerve Sheath Tumours	3 (5)	33
Other	3 (5)	78
Histologic grade, n (%)			.015	.030	2.26 (1.08–4.58)
Low grade (G1)	21 (34)	92
Intermediate grade (G2)	11 (18)	54
High grade (G3)	29 (48)	43
AJCC 8th Ed., n (%)			.511
Stage IA	2 (3)	94
Stage IB	17 (28)	88
Stage II	4 (7)	68
Stage IIIA	8 (13)	59
Stage IIIB	25 (41)	42
Stage IV	5 (8)	19
Chemotherapy n (%)			.423
None	49 (80)	61
Neoadjuvant	2 (3)	51
Adjuvant	10 (16)	41
Radiotherapy			.598
None	44 (72)	58
Neoadjuvant	4 (7)	67
Adjuvant	13 (21)	70
Surgical resection margin			.186
R0	33 (54)	61
R1	18 (30)	45
R2	2 (3)	0
RX / Not stated	8 (13)	48
Vascular involvement			.333
Yes	17 (28)	36
No	44 (72)	62
ASA physical status			.066
I	12 (20)	90
II	32 (52)	63
III	14 (23)	56
IV	3 (5)	42
Need for intraoperative transfusions, %			.303
No RBCC	32 (52)	56
1–2 RBCC	13 (21)	59
≥ 3 RBCC	16 (26)	30

* Cox regression multivariate analysis included all variables with P < 0.05 in univariate analysis. CI Confidence interval, NS Not significant, BMI Body-mass-index, ASA American Society of Anesthesiologists, AJCC American Joint Committee on Cancer Staging Manual, NOS Not otherwise specified, RBCC Red blood cell concentrate
Entries with a p-value of < 0.05 in univariate or multivariate analysis are in boldface. A P value below 0.05 was considered significant.

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