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Table 1 Baseline characteristics of the included studies

From: Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis

Reference Year Study design Age (years)a GA (weeks)a No. of Women Negative appendectomy (%) Complicated appendicitis (%) Outcomes
Total LA OA
Yoo et al. [16] 2016 Retrospective 30.8 20.2 80 24 56 NA 31.3 Fetal loss, preterm delivery, LOS, operative time, birth weight, wound infection, intraabdominal abscess
Karaman et al. [17] 2016 Retrospective 22.8 24.9 48 12 36 NA NA Fetal loss, preterm delivery, LOS, operative time, Apgar score, birth weight, wound infection, intraabdominal abscess
Cox et al. [30] 2016 Retrospective 27.9 NA 1335 894 441 NA 9.0 Operative time, wound infection, LOS, intraabdominal abscess
Cheng et al. [18] 2015 Retrospective NA NA 781 128 653 NA 15.5 Fetal loss, preterm delivery, LOS
Peled et al. [19] 2014 Retrospective 28.1 17.9 85 26 59 17.6 12.9 Fetal loss, preterm delivery, LOS, Apgar score, birth weight,
Kapan et al. [31] 2013 Retrospective 26.2 17.5 17 7 10 NA NA Fetal loss, LOS, operative time,
Chung et al. [20] 2013 Retrospective 30.6 16.6 61 22 39 9.8 11.5 Fetal loss, preterm delivery, LOS, operative time, Apgar score, birth weight, wound infection, intraabdominal abscess
Miloudi et al. [32] 2012 Retrospective NA NA 27 16 11 NA 14.8 Fetal loss
Khan et al. [21] 2012 Retrospective 22.8 17.3 118 52 66 NA NA Fetal loss, preterm delivery, LOS, operative time, wound infection, intraabdominal abscess
Jung et al. [22] 2012 Retrospective 27.9 15.4 25 4 21 0 NA Fetal loss, preterm delivery, LOS, wound infection
Eom et al. [23] 2012 Retrospective 29.1 38.7 43 15 28 0 23.3 Fetal loss, preterm delivery, LOS, operative time, birth weight, intraabdominal abscess
De Bakker et al. [24] 2011 Retrospective NA NA 15 12 3 3.0 NA Fetal loss, preterm delivery, LOS, operative time
Sadot et al. [25] 2010 Retrospective 29.5 19.7 65 48b 17b 24.1 12.3 Fetal loss, preterm delivery, LOS, operative time, Apgar score, birth weight, wound infection
Corneille et al. [26] 2010 Retrospective 25.6 (6.4) 15.9 (8.4) 49 9 40 NA NA Fetal loss, preterm delivery, LOS
Kirshtein et al. [3] 2009 Retrospective 28.4 13.9 (6.0) 42 23 19 42.9 19.0 Fetal loss, LOS, operative time, Apgar score, birth weight, wound infection
Upadhyay et al. [33] 2007 Prospective 27.2 (3.3) 32 (2.6) 6 4 2 NA NA Fetal loss, preterm delivery
McGory et al. 2007 Retrospective 27.2 (6.0) NA 3133 454 2679 23.1 25.3 Fetal loss
Carver et al. [34] 2005 Retrospective 23.4 (5.8) 14 (5.4) 28 17 11 NA NA Fetal loss, preterm delivery, LOS, Apgar score, birth weight, wound infection
Lyass et al. [36] 2001 Prospective 28.5 (15.2) 20 (6.3) 22 11 11 31.8 0 Fetal loss, preterm delivery, LOS, operative time
Affleck et al. [37] 1999 Retrospective NA NA 37 19 18 NA NA Fetal loss, preterm delivery
Gurbuz et al. [38] 1997 Prospective 24.5 (1.5) 20.1 (9.0) 9 5 4 NA NA Fetal loss, preterm delivery, LOS, operative time
Curet et al. [39] 1996 Retrospective NA NA 11 4 7 NA NA Fetal loss
  1. aValues are the means (standard deviations)
  2. bMissing data, 41 vs 16
  3. NA not available, GA gestational age, LA laparoscopic appendectomy, OA open appendectomy, LOS length of stay