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Table 1 Literature Review Summary Table

From: Diagnosis and management of a mediastinal ectopic thyroid laying on the right bronchus: case report and review of literature

Year

Author

Country

Title

Conclusions

2016

Cao L, et al. [1]

China

Clinical Characteristic and molecular pathology of skull ectopic thyroid cancer

The ETT was correlated with Akt/mTOR pathway high expression; orthotopic thyroid was related with MAPK/BRAF/ERK signaling pathway high expression; and the metastatic thyroid cancer was related with NFkB/MMP9 high expression.

2013

Ko HH, et al. [2]

Korea

Ectopic intrapulmonary thyroid: a case report

In this case the patient was previously operated for thyroid cancer and later an ectopic intrapulmonary thyroid was discovered at the follow-up.

2013

Wang SC, et al. [3]

Taiwan

Ectopic Thyroid Tissue in the Adrenal Gland Mimicking a Pheochromocytoma

Ectopic thyroid tissue occurring in the adrenal gland is extremely rare. Tsujimura t al. [11] reported the first case of ETTAG in 1996.2 Until now, there have been only 11 cases reported in the literature.

2017

Tamaki S, et al. [4]

Japan

Laparoscopic resection of retroperitoneal ectopic thyroid tissue

This case shows the unusual finding of ectopic thyroid tissue in the retroperitoneum and the usefulness of laparoscopy for resecting such masses.

2003

Gamblin TC, et al. [5]

USA

Ectopic thyroid

Here is presented a case of ETT extended from the thoracic inlet inferiorly, anterior to the heart, with severe tracheal deviation to the patient’s right.

2004

De Felice M, et al. [6]

Italy

Thyroid development and its disorders: genetics and molecular mechanisms

Gene-targeting experiments have demonstrated that Foxe1 is required for thyroid migration and that mice homozygous for Foxe1 mutations show a sublingual thyroid.

2013

Nettore IC, et al. [7]

Italy

The molecular causes of thyroid dysgenesis: a systematic review

Several mutations in genes playing a role during thyroid morphogenesis such as NKX2-1, PAX8, FOXE1, NKX2-5, TSHR, have been reported in ETT

2010

Abu-Khudir R, et al. [8]

Canada

Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands

This study analyzed gene expression, genome-wide methylation, and structural genome variations in normal versus ETT, demonstrating a differential gene expression in ETT.