Fig. 3

Macroscopic image and histological examination of the resected left adrenal specimen. Multiple macro-nodular lesions were found in the surgical specimen (a). Multiple capsulated nodules that were composed of large clear cells and small compact cells were identified by macroscopic examination. (b: magnification ×20, c: magnification ×100) Immunohistochemical staining showed large clear cells were positive for HSD3β2 (d: magnification ×100), and small compact cells were positive for CYP17 (e: magnification ×100). In the non-nodular adrenal cortex of zona glomerulosa, small cell clusters with positive immunostaining for CYP11β2 were identified, but not within the nodules. (f: magnification ×10, g: magnification ×100)