Fig. 2
From: Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers
Experimental setup consisting of 3 test arms. The first test arm entailed oral or intravenous (i.v.) administration of atorvastatin (ATV) without subjecting the animals to ischemia/reperfusion (I/R) to determine the effect of ATV on the pathology of cholestasis. This test arm also served to demonstrate that ATV is targeted to the liver following oral or i.v. administration. Test arms 2 and 3 encompassed i.v. administration of ATV followed by I/R. The gray segment delineates the period of bile duct ligation (BDL), the blue segment indicates the ischemic phase, and the red segment designates the reperfusion time frame. The times in in every segments at which procedures were performed are indicated with black vertical lines, protracted in gray throughout the figure. The legend at the top explains the significance of the symbols, the numbers in parentheses refer to the group size