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Table 3 Univariate analysis of potential prognostic factors for progression-free survival (n = 35 patients) and disease-free survival (n = 35 patients) following metastasectomy of primary and hepatic metastasic lesions, respectively

From: The value of hepatic resection in metastasic renal cancer in the Era of Tyrosinkinase Inhibitor Therapy

   Progression-free Survival after first Metastasectomy   Disease-free Survival after Liver-directed therapy (LDT)  
Variables n Median Time (months) with IQR p-value Median Time (months) with IQR p-value
Gender      
 Male 24 8 (5–44) 0.324 15 (5–44) 0.346
 Female 11 27 (10–47)   20 (9–58)  
Targeted therapy      
 TKI+ 16 47 (18–79) 0.023 58 (18–79) 0.110
 TKI– 19 19 (6–39)   19 (4–46)  
ECOG      
 0 29 29 (10–47) 0.015 20 (8–71) 0.132
 > 1 6 6 (2–28)   15 (1–28)  
Age      
 < 65 years 18 19 (8–40) 0.518 19 (5–71) 0.960
 > 65 years 17 39 (8–71)   20 (9–58)  
Tumor distribution      
 unilobular 28 28 (8–44) 0.772 28 (8–58) 0.981
 multilobular 7 19 (3–77)   19 (3–79)  
Extrahepatic Disease      
 Yes 28 27 (7–45) 0.412 19 (8–59) 0.962
 No 7 29 (4–82)   20 (4–29)  
Liver metastasis Timing      
 Synchronous 6 4 (2–9) 0.035 4 (2–8) 0.085
 Metachronous 29 28 (10–47)   26 (12–58)  
Tumor size, cm      
 < 4.5 cm 21 39 (10–71) 0.07 19 (9–42) 0.376
 > 4.5 cm 14 18 (6–29)   18 (5–35)  
Resection margin      
 Radical resection (R0) 30 28 (12–51) 0.001 28 (12–58) 0.014
 Irradical resection (R1/R2) 5 6 (3–10)   4 (3–9)  
Number of metastases      
 Solitary 22 27 (8–47) 0.653 28 (9–51) 0.967
 Multiple 13 19 (8–40)   19 (5–79)  
Grading of RCC      
 Low (G1/G2) 24 40 (18–71) 0.002 44 (18–71) 0.001
 High (G3/G4) 11 8 (5–19)   8 (4–19)  
T-stage      
 T1/T2 16 44 (12–79) 0.027 29 (15–71) 0.071
 T3/T4 19 18 (6–39)   18 (4–51)  
Disease-free intervall      
 < 12 months 17 28 (5–79) 0.753 28 (5–79) 0.501
 > 12 months 18 27 (10–40)   19 (9–58)  
  1. TKI Tyrosinkinase InhibitorTherapy, ECOG Eastern Cooperative Oncology Group
  2. The bold data specifies a staticial significance p-values < 0.05