Table 3 Dose modification protocol according to the level of adverse reaction caused by capecitabine therapy (Toxicity according to NCI CTC Version 3.0)
Toxicity | occurrence | suggested measure | dose during following cycle (% of original dose) |
|---|---|---|---|
1 | continue with current dose | 100% | |
2 | 1st occurrence | discontinue treatment till restitution to grade 0 or 1 toxicity | 100% |
2nd occurrence | discontinue treatment till restitution to grade 0 or 1 toxicity | 75% | |
3rd occurrence | discontinue treatment till restitution to grade 0 or 1 toxicity | 50% | |
4th occurrence | final discontinuation of treatment | - | |
3 | 1st occurrence | discontinue treatment till restitution to grade 0 or 1 toxicity | 75% |
2nd occurrence | discontinue treatment till restitution to grade 0 or 1 toxicity | 50% | |
3rd occurrence | final discontinuation of treatment | - | |
4 | 1st occurrence | final discontinuation of treatment or discontinuation till restitution to grade 0 or 1 toxicity | 50% |