Table 7 Tabulated summary of the specific analyses of failed or false negative analysis where such has been explicitly contained within the publication.
Authors | Year | Comment |
|---|---|---|
Bendavid [56] | 2002 | The one false negative case occurred in a patient with liver metastases. Also 'evidently metastatic nodes' did not receive colourant |
Paramo [57] | 2002 | No specific analysis presented. |
Wood [58] | 2002 | All five false negatives occurred in T3 or T4 tumors (in one case the only positive non-sentinel node was involved by direct extension). Three occurred in 1st 30 cases |
Bilchik [59] | 2002 | All five false negatives occurred in T3 or T4 tumors. Three occurred in the first fifty cases. |
Kitagawa [60] | 2002 | Four false negative cases were advanced T3 and/or had massive lymph node metastases |
Feig [61] | 2002 | Also 'several patients' (of ten) classified as false negative had 'palpable lymph nodes' |
Broderick-Villa [62] | 2002 | Learning curve strongly associated with false negative rate (67% in first half, 32% in second half). No significant association with T-stage, LN involvement or tumor diameter > or < 4 cm |
Veihl [70] | 2003 | Amount of dye relative to tumor size was an important predictor of identification of node. False negative more common in cases with larger nodes (4.5 cm v 3.4 cm, p = 0.09) |
Bilchik [83] | 2006 | Of the six false negatives, four were attributable to tumor obliteration of the lymphatic channels |
Saha [85] | 2006 | 95% of patients with skip metastases were T3 or T4 |
Thomas [87] | 2006 | Two patients with liver metastases along with two others with gross mesenteric disease had false positive sentinel nodes. No relationship between BMI and disease |
Kelder [89] | 2006 | In one of the two false negatives, the non-SLNs were involved by extra-nodal tumor invasion |
Bembenek [92] | 2007 | Significant association with learning curve/center experience, BMI (cut-off level being 22 patients and a BMI of 25 respectively) & LVI. No significant association between detection and T stage, age, sex, vascular invasion, no of nodes, total no of nodes. |
Sandrucci [93] | 2007 | 'Skip metastases' were all correlated with 'T2 lesions with massive lymphatic involvement' |
Tiffet [94] | 2007 | Three of 12 false negatives were in patients with direct tumor involvement of adjacent non-sentinel epicolic nodes while four were in N2 patients. False negative rate markedly lower in the subgroup with T1 and T2 tumors only. and in those with BMI < 30 kg/m2 |