From: “Clinical significance of multifocal and multicentric breast cancers and choice of surgical treatment: a retrospective study on a series of 1158 cases”
HR
95% C.I.
p
multifocal/multicentric breast cancer
present
1.64
1.05-2.57
0.029
Estrogen receptors
absent
1.89
1.2-2.98
0.005
Mib-1
>15%
1.85
1.4-3.02
0.013
Nodal status
pN0
1
pN1
1.73
0.87-3.22
0.116
pN2
3.08
1.53-6.16
0.002
pN3
9
4.95-16.4
<0.001