Gastrointestinal stromal tumor: 15-years’ experience in a single center

BMC Surgery

Table 4 Univariate analysis of OS and RFS in 401 GIST patients

Clinicopathological feature	Group	N	OS			RFS
Clinicopathological feature	Group	N	5-year OS (%)	χ²	P-value	5-year RFS (%)	χ²	P-value
Gender	Male	221	80.2	6.590	0.010	71.6	8.914	0.003
	Female	180	90.6			84.4
Age	<60	197	85.7	1.573	0.210	77.4	0.011	0.917
	≥60	204	84.0			77.4
Tumor site	Gastric	241	86.5	1.969	0.161	86.1	18.876	<0.001
	Non-gastric	160	82.5			65.3
Tumor size	≤2 cm	51	100	110.281	<0.001	100	146.144	<0.001
	2.1-5 cm	178	98.0			94.6
	5.1-10 cm	109	80.9			66.8
	>10 cm	63	49.2			33.5
Mitotic rate	<5/50 HPF	296	95.9	83.348	<0.001	91.2	152.472	<0.001
	5-10/50 HPF	44	68.0			55.3
	>10/50 HPF	61	54.2			33.7
Risk class	Very low	39	100	66.044	<0.001	100	154.234	<0.001
	Low	172	99.1			98.1
	Intermediate	51	89.6			90.9
	High	139	65.9			44.5
CD117 expression	Positive	350	83.4	3.315	0.069	76.6	1.401	0.237
	Negetive	51	95.1			82.6
CD34 expression	Positive	322	87.2	7.564	0.006	80.6	10.777	0.001
	Negative	79	75.4			64.3
SMA expression	Positive	101	90.6	1.559	0.212	83.2	2.246	0.134
	Negative	300	83.2			75.6
S-100 expression	Positive	84	88.2	1.377	0.241	74.0	0.529	0.467
	Negative	317	83.7			78.5
Adjacent involvement	Without	336	92.1	66.176	<0.001	87.2	147.885	<0.001
Adjacent involvement	With	65	53.0			30.8

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