Table 1 Gene mutations in ATC
From: Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review
Gene | Mutation | Signaling involvement |
|---|---|---|
RET | Recombination | MAPK activation |
BRAF | Single point mutation | MAPK activation |
H-, N-, K-RAS | Single point mutation | MAPK, PI3K/Akt/mTOR activation |
PTEN | Single point mutation/deletion | PI3K/Akt/mTOR inactivation |
PI3KCA | Single point mutation | PI3K/Akt/mTO activation |
TP53 | Single point mutation | P53 pathway inactivation |