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Multiple lymphomatous polyposis with diffuse involvement of the gastrointestinal tract: a case report


The gastrointestinal tract is the predominant site of appearance of extranodal non-Hodgkin lymphomas. Multiple lymphomatous polyposis (MLP) is a type of manifestation of mantle cell lymphoma (MCL) and it is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for only approximately 1-2% of non Hodgkin lymphomas.


A 78 years old patient was admitted to our Department of General Surgery with rectal bleeding, abdominal pain and weight loss. Multiple lymphomatous polyposis was detected on the endoscopic evaluations, i.e. upper GI endoscopy and colonoscopy. Abdominal and pelvis TC revealed anomalies of the rectum wall, pelvic lymphadenopaty and two liver metastasis. Abdominal and pelvis RM showed lombo-aortic lymphadenopaty and massive thickening of the rectum. Total body PET-TC detected rachis involvement, specifically at D1, L2 and L3 vertebrae, and an intense signal of the whole ileum.


Histopathologic study of biopsies from gastrointestinal specimens showed a lymphoid infiltrate. Immunoistochemical evaluation confirmed that the lymphoma was positive for CD20 and CYCLIN D1 and negative for CD10, CD23 and CD5, features suitable with diagnosis of non-Hodgkin’s mantle lymphoma. Bone narrow biopsy was negative for lymphoid proliferation. The patient was sent to Department of Hematology to receive cycles of chemioterapy.


MCL is an uncommon entity of primary GI NHL with particular clinic, morphological and immunophenotypic features. Clinically, patients with a diagnosis of MCL are often elderly adults with a male predominance and present a disease in an advanced stage. Abdominal pain, diarrhea, hematochezia and organomegaly are the most common presenting manifestations. Because this lymphoma occurs in the elderly population, stem cell transplantation is not possible. GI lymphomatous polyposis is a rare disease, but in all elderly patients with a widespread polyposis of the GI tract a diagnosis of lymphoma must be considered.


  1. Penyige J, Farczadi E, Boer K, et al: A rare intestinal malignancy: mantel cell lymphoma. Endoscopy. 2007, 39: E60-10.1055/s-2006-944892.

    Article  PubMed  Google Scholar 

  2. Meral M, Demirpence M, et al: Diffuse gastrointestinal involvement of mantle cell lymphoma. Turk J Gastroenterol. 2008, 19 (2): 117-120.

    PubMed  Google Scholar 

  3. Michopoulus S, Petraki K, Matsouka C, et al: Mantle-cell lymphoma (multiple lymphomatous polyposis) of the entire GI tract. Clinical Oncology. 2008, 20: 1555-1557.

    Article  Google Scholar 

  4. Martin P, Coleman M, Leonard JP: Progress in mantle-cell lymphoma. J Clin Oncol. 2009, 27: 481-3.

    Article  PubMed  Google Scholar 

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Correspondence to Giovanni Cestaro.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cestaro, G., De Rosa, M., Vitiello, C. et al. Multiple lymphomatous polyposis with diffuse involvement of the gastrointestinal tract: a case report. BMC Surg 13 (Suppl 1), A7 (2013).

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  • Lymphoma
  • Hodgkin Lymphoma
  • Mantle Cell Lymphoma
  • Polypoid Lesion
  • Immunophenotypic Feature