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Table 1 Characteristics of included studies

From: Topical haemostatic agents for skin wounds: a systematic review

Trial Patients Intervention Comparison Outcomes
Barret JP, 1999 42 pediatric burn patients (21 vs. 21) Epinephrine 1:10.000 (and thrombin 1:300.000) (topical) Saline (and thrombin) Blood loss in ml and ml/cm2, Ht, Hb up to 8 hours post-operatively, blood transfusions
Brezel BS, 1987 32 burn patients (32 vs. 32) Epinephrine 1:200.000 (topical) Thrombin Blood loss visually estimated from photographs 5 minutes post-operatively
Gacto P, 2008 56 burn patients (25 vs. 31) Epinephrine-lidocaine Subcutaneous 1:500.000 Saline Overall blood loss visually estimated, use of electrocautery, days hydrocolloid maintained
Netscher DT, 1996 52 patients (12 vs. 8 vs. 12 vs. 7 vs. 13) Epinephrine/K-Y jelly 1:50.000 (topical) Epinephrine spray, thrombin, K-Y jelly, mineral oil. Time to haemostasis (minutes)
Carucci DJ, 1984 24 patients (6 vs. 6 vs. 12) Phenylephrine 1:20.000 (topical) Thrombin Blood loss measured by Hb in paper disks
Greenhalgh DG, 1999 34 burn patients (<15% TBSA) (34 vs. 34) Fibrin sealant (duoflo Y-shaped adapter) Placebo Blood loss visually estimated and measured by Hb in sponges, donor site healing viewed on photographs
Nervi C, 2001 61 burn patients (donor site 2-8% TBSA) (61 vs. 61) Fibrin sealant (duoflo Y-shaped adapter) Placebo Time to haemostasis
Drake DB, 2003 34 patients with SSG areas 5-15 cm (34 vs. 34) Fibrin sealant (Vivostat) Thrombin Time to haemostasis (seconds)
Steenfos HH, 1998 5 patients (7 donor sites) (7 vs. 7) Alginate dressing Fine mesh gauze Blood loss measured by iron content of dressings