Table 1 Characteristics of included studies
From: Topical haemostatic agents for skin wounds: a systematic review
Trial | Patients | Intervention | Comparison | Outcomes |
|---|---|---|---|---|
Barret JP, 1999 | 42 pediatric burn patients (21 vs. 21) | Epinephrine 1:10.000 (and thrombin 1:300.000) (topical) | Saline (and thrombin) | Blood loss in ml and ml/cm2, Ht, Hb up to 8 hours post-operatively, blood transfusions |
Brezel BS, 1987 | 32 burn patients (32 vs. 32) | Epinephrine 1:200.000 (topical) | Thrombin | Blood loss visually estimated from photographs 5 minutes post-operatively |
Gacto P, 2008 | 56 burn patients (25 vs. 31) | Epinephrine-lidocaine Subcutaneous 1:500.000 | Saline | Overall blood loss visually estimated, use of electrocautery, days hydrocolloid maintained |
Netscher DT, 1996 | 52 patients (12 vs. 8 vs. 12 vs. 7 vs. 13) | Epinephrine/K-Y jelly 1:50.000 (topical) | Epinephrine spray, thrombin, K-Y jelly, mineral oil. | Time to haemostasis (minutes) |
Carucci DJ, 1984 | 24 patients (6 vs. 6 vs. 12) | Phenylephrine 1:20.000 (topical) | Thrombin | Blood loss measured by Hb in paper disks |
Greenhalgh DG, 1999 | 34 burn patients (<15% TBSA) (34 vs. 34) | Fibrin sealant (duoflo Y-shaped adapter) | Placebo | Blood loss visually estimated and measured by Hb in sponges, donor site healing viewed on photographs |
Nervi C, 2001 | 61 burn patients (donor site 2-8% TBSA) (61 vs. 61) | Fibrin sealant (duoflo Y-shaped adapter) | Placebo | Time to haemostasis |
Drake DB, 2003 | 34 patients with SSG areas 5-15 cm (34 vs. 34) | Fibrin sealant (Vivostat) | Thrombin | Time to haemostasis (seconds) |
Steenfos HH, 1998 | 5 patients (7 donor sites) (7 vs. 7) | Alginate dressing | Fine mesh gauze | Blood loss measured by iron content of dressings |