Table 2 Gender specific adiponectin and leptin levels and resistin, MCP-1, active PAI-1, TNF-α, IL-1α, IL-6, IL-8, and IL-10 levels of septic patients (SP), morbidly obese (MO) and controls (BD).
|
Parameters (normal values) |
SP (n = 33) (Median; range) |
MO (n = 37) (Median; range) |
BD (n = 60) (Median; range) |
Change SP vs. BD |
Change MO vs. BD |
|---|---|---|---|---|---|
|
Adiponectin
(μg/ml) |
10.3
(2.9 - 47.6) |
9.4
(3.8 - 57.8) |
14.7
(5.7 - 54.0) |
↓
p = < 0.01 |
↓
p = < 0.01 |
| Adiponectin male (μg/ml) |
9.5
(2.9 - 32.6) |
8.3
(3.8 - 12.3) |
11.8
(5.7 - 30.7) |
↓
p = 0.04 |
↓
p = < 0.01 |
| Adiponectin female (μg/ml) |
13.2
(5.3 - 47.6) |
12.4
(5.3 - 57.8) |
22.5
(9.8 - 54.0) |
↓
p = 0.02 |
↓
p = < 0.01 |
| Leptin (ng/ml) |
6.3
(0.3 - 80.7) |
45.0
(1.7 - 97.5) |
10.8
(0.3 - 58.5) | no significant change |
↑
p = < 0.01 |
|
Leptin male (ng/ml) (< 7 ng/ml) |
6.3
(0.3 - 24.7) |
34.2
(1.7 - 90.9) |
4.6
(0.3 - 19.1) | no significant change |
↑
p = < 0.01 |
|
Leptin female (ng/ml) (< 18 ng/ml) |
8.2
(0.9 - 80.7) |
47.3
(16.1 - 97.5) |
15.8
(0.7 - 58.5) | no significant change |
↑
p = < 0.01 |
| Resistin (ng/ml) |
78.1
(13.4 - 52.3) |
9.9
(3.7 - 83.6) |
10.8
(5.2 - 24.9) |
↑
p = < 0.01 | no significant change |
| MCP-1 (pg/ml) |
381.5
(72.3 - 887.3) |
108
(39.6 - 293) |
43.9
(12.1 - 150) |
↑
p = < 0.01 |
↑
p = < 0.01 |
| Active PAI-1 (ng/ml) |
35.9
(11.5 - 160.3) |
57.5
(3.7 - 176.7) |
6.0
(2.4 - 31.3) |
↑
p = < 0.01 |
↑
p = < 0.01 |
| TNF-α (pg/ml) |
13.1
(2.4 - 65.5) |
4.0
(2.4 - 26.8) |
3.9
(1.2 - 10.9) |
↑
p = < 0.01 | no significant change |
| IL-1α (pg/ml) |
68.6
(9.2 - 203.3) |
59.4
(9.2 - 210.0) |
11.0
(9.2 - 168) |
↑
p = 0.04 |
↑
p = 0.01 |
| IL-6 (pg/ml) |
163.6
(14.4 - 10000) |
2.9
(0.9 - 64.2) |
0.7
(0.4 - 568.6) |
↑
p = < 0.01 |
↑
p = < 0.01 |
| IL-8 (pg/ml) |
59.4
(4.6 - 1335.6) |
3.7
(0.3 - 38.8) |
9.8
(0.9 - 126.7) |
↑
p = < 0.01 |
↓
p = < 0.01 |
| IL-10 (pg/ml) |
26.7
(3.9 - 276.7) |
2.5
(2.4 - 8.6) |
1.2
(0.9 - 1038) |
↑
p = < 0.01 |
↑
p = 0.01 |