All Participants | Â |
---|---|
Inclusion | Exclusion |
1. Undergoing thoracic and/or lumbar surgery for correction of condition via posterior spinal fusion of greater than 6 levels | 1. No renal dysfunction identified by elevated blood urea nitrogen (BUN) and creatinine (CR) or BUN to CR ratio greater than 20:1 |
 | 2. Hold religious and/or other beliefs limiting blood transfusion |
 | 3. Currently use anti-coagulant medication or have past medical history leading to abnormal coagulation profile pre-operatively |
 | 4. Significant past medical history preventing the use of TXA or EACA described in the protocol |
AIS | Â |
Inclusion | Exclusion |
1. Between 10 and 21 years of age | 1. Previous corrective spinal surgery that is being revised |
2. BMI between 5th and 95th percentiles | Â |
AD | Â |
Inclusion | Exclusion |
1. Between 18 and 80 years of age | 1. Any history of coronary artery disease with stent placement |
NMS | Â |
Inclusion | Exclusion |
1. Between 10 and 80 years of age | 1. Congenital and syndromic scoliosis |
 | 2. Previous corrective spinal surgery that is being revised |