Volume 12 Supplement 1
Usefulness of a fast track list for anxious patients in a upper GI endoscopy
© Cardin et al; licensee BioMed Central Ltd. 2012
Published: 15 November 2012
To determine whether patients with no alarm signs who ask the endoscopist to shorten their waiting time due to test result anxiety, represent a risk category for a major organic pathology.
At our open-access endoscopy service, we set up an expedite list for six months for outpatients who complained that the waiting time for gastroscopy was too long. Over this period we studied 373 gastroscopy patients. In addition to personal details, we collected information on the presence of Hp infection and compliance with dyspepsia guideline indications for gastroscopy.
Average waiting time was 38.2 days (SD 12.7). The 66 patients who considered the waiting time too long underwent gastroscopy within 15 days. We made 5 diagnoses of esophageal and gastric tumour and gastric ulcer (7.6%) among the expedite list patients and 14 (4.6%) among those on the normal list (p=0.31). On including duodenal peptic disease in the analysis, the total prevalence rate rose to 19.7% in the short-wait group and to 10.4% (p=0.036) in the longer-wait group.
Discussion and conclusions
Our data suggests that asking to be fast-tracked does not have prognostic impact on the diagnosis of a major (gastric ulcer and cancer) pathology.
There is a well-known close association between endoscopy waiting times and test results in urgent referrals, particularly in the case of digestive bleeding . Clinical progress of malignancy is also influenced by time to exam  and this event may have also medical-legal consequences . From an organizational stand point, this evidence has led to the creation of on-call services for urgent endoscopy and implementation of the two-week rule for endoscopyreferrals.
No such association between waiting time and endoscopy outcomes has instead been observed for dyspepsia, yet endoscopists working in very busy services are often asked to fast-track patients withnon-medically urgent conditions and dyspeptic symptoms, leading to organizational problems.
Some requests are made by general practitioners but everyday experience and experimental evidence have shown that considerable pressure on specialist services is brought to bear directly by patients, particularly those affected by functional pathology . The key to patient management in dyspepsia guidelines is endoscopy timing: referral is immediate in the presence of red flags but postponed until outcome of symptomatic treatment in young patients . It is not clear, however,whether patient requests to be fast-tracked have prognostic value in relation to symptom severity.
Prognostic characteristics extrapolated from patient self-rating questionnaires have permitted to differentiate between the probability of a functional or organic pathology being present . This observation could be further explored to assess the value of patient insistence or fear of late diagnosis. While generalized anxiety disorder is associated with functional dyspepsia , Hospital Anxiety Depression scale results have shown that patients affected by organic and functional pathology have comparable levels of anxiety and depression prior to endoscopy .
Sonnenberg studied the main principles of queueing theory to prevent under use of endoscopic resources  and various strategies have been studied to give priority to exams with a greater probability of yielding an organic pathology [10–12]. However, endoscopists are faced with a burgeoning array of difficult choices in managing waiting lists, particularly when patients directly ask them to shorten waiting time after bypassing the central appointment service.
The main aim of this study was to examine how accepting patient requests to reduce the waiting time set by the central appointment service impacted gastroscopy outcomes. Specifically we sought to assess whether fast-tracking patients on their request improved identification of organicpathology, to show whether insistence on rapid admission to gastroscopy could be considered an alarm sign for organic dyspepsia and, possibly, to suggest an effective management approach to these patients. Accordingly, over a period of six months, our open-access endoscopy clinic agreed to fast-track outpatients who believed their symptoms demanded prioritized medical attention.
Over a six-month period, at an open-access service operating in Padova, an industrial town in North-east Italy with 390,000 residents, we prospectively studied the results of esophagogastro-duodenoscopy(EGDS) procedures of outpatients affected by dyspepsia, in relation to their waitingtime.
We stratified the study patients by sex, age (≤45 and >45 years), presence of Helicobacter pylori(Hp) infection and appropriateness of endoscopy referral according to international dyspepsia guidelines .
For each patient we calculated the time elapsing between GP referral for gastroscopy and the procedure date, classifying waiting times as ≤15 and >15 days. The study also included patient referrals for follow-up endoscopy. We differentiated waiting times by activating an expedite examination list composed of patients who, directly or through a third person, expressed concern tothe endoscopist about the length of waiting time set by the central appointment service, and askedfor prioritized medical attention.
The study excluded inpatients or patients with medically urgent conditions, as digestive bleeding, or patients referred by a gastroenterologist. To account for differences in clinical management of gastric and duodenal ulcer, we performed two sets of analysis. One included only diagnoses ofgastric ulcer and gastric or esophageal cancer. The other set also included the presence of duodenalulcer.
The chi square (χ2) test was used to compare differences between the two groups and the two sets of positive gastroscopies (first set: carcinoma plus gastric ulcer; second set:carcinoma plus gastric and duodenal ulcer). If the chi squared test was not applicable, the analogous non-parametric test (Fisher’s exact test) was used. The SAS statistical software, rel. 9.1.3, was used for the analysis. A p-value<0.05 was considered significant.
Distribution of diagnosed lesions (n=373)
Mean waiting time on the standard list was 38.2 days (SD 12.7). Sixty-six patients were placed on the expedite list.
Distribution of main variables according to waiting time.
Waiting time (%)
≤ 15 days
> 15 days
Compliance with dyspepsia guidelines
Pathologies diagnosed according to two different waiting times
Cancer and gastric ulcer
Cancer and gastric / duodenal ulcer
Waiting time (days)
Our study was prospectively designed to investigate whether patients requesting fast track gastroscopy had a higher incidence of organic pathology. We adopted broad inclusion criteria for expedite list placements in order to emphasize patient concern rather than medical priority criteria.
Our observations suggest that accepting patients’ requests to reduce waiting time, by creating aspecial expedite list to manage gastroscopies within an open-access upper-endoscopy service, doesnot provide substantial diagnostic gains.
While the two study groups were comparable in terms of recognized prognostic elements as age, Hpinfection and sex, they differed in compliance with guideline indications for endoscopy. Despite this lack of homogeneity favouring the expedite group, there was not a substantial increase in the number of diagnosed organic pathologies among the expedite list patients. Only when assessment of the positive diagnoses included duodenal ulcer was there a significant difference between the two groups in the number of organic pathology diagnoses. This may be because the study has a type-2 limit related to the small number of organic diagnoses or, as recently demonstrated, be due to a difference in the acuteness of dyspeptic symptoms for duodenal ulcer , or a higher prevalence of painful symptoms .
In any event, our case series was characterised by a higher prevalence of organic pathologies than reported in other studies [16, 17]. Moreover, to avoid a type-2 error we would have had to collect an almost unrepeatable number of malignancy diagnoses. It is, however, worth stressing that the painsymptom caused by a probable duodenal ulcer is what forces patients to ask for a reduction inwaiting time . In our opinion, this is an important management finding, insofar as an antacidtherapy could be prescribed to patients who cannot be fast-tracked.
We also believe our data generally confirm observations that the presence of alexithymia is associated with more severe symptoms during the week preceding endoscopy , although it does not differ in patients with organic and functional pathology.
Our decision to assess the importance of patient intervention in priority setting was partly influenced by explicit reference, in the latest revision of the NICE guidelines, to patients’ fear that amalignancy was present . However, unlike the results of another Italian case series, reduced waiting times did not correspond to a higher number of positive diagnoses. Findings also differed because Parente’s strategy was based on participation in a regional scheme to reduce endoscopy waiting times and thus prioritization was more dependent on physician evaluation . In any event, prioritizing endoscopy waiting lists in order to identify gastrointestinal malignancies earlierand in higher numbers has been criticized, even in the case of the two-week rule, because it canseriously affect endoscopy service activities by lengthening other waiting lists .
Conversely, our findings also showed that patients who agreed to wait longer for the procedure did not have a zero risk of malignancy. The diagnostic curves for waiting times exhibited a relative increase in positive malignancy diagnoses in patients waiting longer. This may be associated, on the one hand, with greater diagnostic yield for advanced lesions and, on the other, with the role of follow-up procedures that are booked irrespective of the presence of symptoms for the precancerous pathologies included in our study.
It would have been interesting to extend our observations to determine whether a “target wait”principle, similar to the one adopted by Smith , reduced the number of failures to attendendoscopy, which is another organizational problem facing endoscopy services . Unfortunately,we were unable to do so. It is also difficult to weigh up the potential benefits for general healthspending that result from reducing the amount of time patients are exposed to test result anxiety.
Considering therefore that the marked increase in endoscopy workload did not lead to earlier detection of esophageal or gastric malignancy , in order to aid diagnostic yield and reduce time to endoscopy, it would be helpful to identify any other potential alarm symptoms that have not yet been studied but have shown poor diagnostic yield in identifying organic pathology [26, 27], as weight loss, irrepressible vomiting, and age.
We relied solely on univariate analysis to derive the poor prognostic impact of patient fear of a latediagnosis. In multivariate analysis the impact of this variable would not have been independent ofother robust predictive elements, as age, sex and Hp infection.
Our findings also suggested that one method of managing patients, who ask to be fast tracked when faced with a long wait for endoscopy, is to prescribe antisecretory therapy to control pain, since theliterature suggests that this does not affect endoscopic diagnosis . Alternatively, patients couldbe screened for psychiatric disorders via a structured psychiatric interview .
While shortening waiting times in anxious patients may be effective in cutting costs, asshown by other studies , it does not help to identify cases of organic dyspepsia.
This article has been published as part of BMC Surgery Volume 12 Supplement 1, 2012: Selected articles from the XXV National Congress of the Italian Society of Geriatric Surgery. The full contents of the supplement are available online at http://www.biomedcentral.com/bmcsurg/supplements/12/S1.
- Lee JG: Urgent endoscopy: does it matter if they don’t listen to us?. Gastrointest Endosc. 2004, 60: 94-5. 10.1016/S0016-5107(04)01533-0.View ArticlePubMed
- Spahos T, Hindmarsh A, Cameron E, Tighe MR, Igali L, Pearson D, Rhodes M, Lewis MP: Endoscopy waiting times and impact of the two week wait scheme on diagnosis and outcome ofupper gastrointestinal cancer. Postgrad Med J. 2005, 81: 728-30. 10.1136/pgmj.2004.031104.PubMed CentralView ArticlePubMed
- Di Pietra L, Gardiman M, Terranova C: Postpartum maternal death associated with undiagnosed Hodgkin's lymphoma. Med Sci Law. 2012, 52 (3): 174-7. 10.1258/msl.2012.011137.View ArticlePubMed
- Little P, Dorward M, Warner G, Stephens K, Senior J, Moore M: Importance of patient pressureand perceived pressure and perceived medical need for investigations, referral and prescribingin primary care: nested observational study. BMJ. 2004, 328: 444-6. 10.1136/bmj.38013.644086.7C.PubMed CentralView ArticlePubMed
- Spiegel BMR, Vakil NB, Ofman JJ: Dyspepsia management in primary care: a decision analysisof competing strategies. Gastroenterology. 2002, 122: 1270-85. 10.1053/gast.2002.33019.View ArticlePubMed
- Bolling-Sternevald E, Carlsson R, Aalykke C, Wilson BV, Junghard O, Glise H, Lauritsen K: Self-administered symptom questionnaires in patients with dyspepsia and their yield indiscriminating between endoscopic diagnoses. Dig Dis. 2002, 20: 191-8. 10.1159/000067482.View ArticlePubMed
- Olden KW, Drossman DA: Psychologic and psychiatric aspects of gastrointestinal disease. MedClin North Am. 2000, 84: 1313-27. 10.1016/S0025-7125(05)70288-1.View Article
- Van Kerkhoven LAS, Van Rossum LGM, Van Oijen MGH, Jansen JBM, Laheij RJF, Tan ACITL: Anxiety,depression and psychotropic medication use in patients with persistent upperand lower gastrointestinal symptoms. Aliment Pharmacol Ther. 2005, 21: 1001-6. 10.1111/j.1365-2036.2005.02435.x.View ArticlePubMed
- Sonnenberg A: Waiting lines in the endoscopy unit. Gastrointest Endosc. 2000, 52: 517-24. 10.1067/mge.2000.108625.View ArticlePubMed
- Kapoor N, Bassi A, Sturgess R, Bodger K: Predictive value of alarm features in a rapid accessupper gastrointestinal cancer service. Gut. 2005, 54: 40-5. 10.1136/gut.2004.039438.PubMed CentralView ArticlePubMed
- Marmo R, Rotondano G, Piscopo R, Bianco MA, Russo P, Capobianco P, Cipolletta L: Combination of age and sex improves the ability to predict upper gastrointestinal malignancy inpatients with uncomplicated dyspepsia: a prospective multicentre database study. Am JGastroenterol. 2005, 100: 784-91. 10.1111/j.1572-0241.2005.40085.x.View Article
- Rutter MD, Michie MB, Trewby PN: The one-stop dyspepsia clinic-an alternative to openaccessendoscopy for patients with dyspepsia. J R Soc Med. 1998, 91: 524-7.PubMed CentralPubMed
- Rubin GP, Meinesche-Schmidt V, Robert AP, Childs SM, de Wit NJ: The management ofHelicobacter Pylori infection in primary care. Eur J Gen Pract. 1999, 5: 98-104. 10.3109/13814789909094271.View Article
- Tahara T, Arisawa T, Shibata T, Nakamura M, Okubo M, Yoshioka D, Wang F, Nakano H, Hirata I: Association of endoscopic appearance with dyspeptic symptoms. J Gastroenterol. 2008, 43: 208-15. 10.1007/s00535-007-2149-2.View ArticlePubMed
- Mansi C, Savarino V, Mela GS, Picciotto A, Mele MR, Celle G: Are clinical patterns ofdyspepsia a valid guideline for appropriate use of endoscopy? A report on 2253 dyspepticpatients. Am J Gastroenterol. 1993, 88: 1011-15.PubMed
- Lieberman D, Fennerty MB, Morris CD, Holub J, Eisen G, Sonnenberg A: Endoscopicevaluation of patients with dyspepsia: results from the national endoscopic data repository. Gastroenterology. 2004, 127: 1067-75. 10.1053/j.gastro.2004.07.060.View ArticlePubMed
- Sundar N, Muraleedharan V, Pandit J, Green JT, Crimmins R, Swift GL: Does endoscopydiagnose early gastrointestinal cancer in patients with uncomplicated dyspepsia?. Postgrad MedJ. 2006, 82: 52-54. 10.1136/pgmj.2005.034033.View Article
- van Kerkhoven LA, van Rijswijck SJ, van Rossum LG, Laheij RJ, Witteman EM, Tan AC, Jansen JB: Open access upper gastrointestinal endoscopy a decade after theintroduction of proton pump inhibitors and helicobacter pylori eradication: a shift in endoscopicfindings. Digestion. 2007, 75: 227-31. 10.1159/000110684.View ArticlePubMed
- van Kerkhoven LA, van Rossum LG, van Oijen MG, Tan AC, Witteman EM, Laheij RJ, Jansen JB: Alexithymia is associated with gastrointestinal symptoms, but doesnot predict endoscopy outcome in patients with gastrointestinal symptoms. J Clin Gastroenterol. 2006, 40: 195-9. 10.1097/00004836-200603000-00005.View ArticlePubMed
- NICE: Dyspepsia. Management of dyspepsia in adults primary care. [http://Guidance.nice.org.uk/CG17]
- Parente F, Bargigga S, Bianchi Porro G: Prospective audit of gastroscopy under the “three-dayrule”: a regional initiative in Italy to reduce waiting time for suspected malignancy. AlimentPharmacol Ther. 2002, 16: 1011-14.
- Boulton-Jones JR, Gamble S, Goddard Wp, Long RG, Teahon K: The impact and clinicalappropriateness of the two wait scheme for suspected cancer. Gut. 2002, 50: a107-11.View Article
- Smith GV, McCartney SA, Bloom SL: Pathology detection and patient age in open access and”target wait” endoscopy- an audit. Gut. 2004, 111: a46-
- Adams LA, Pawlik J, Forbes GM: Non attendance at outpatient endoscopy. Endoscopy. 2004, 36: 402-4. 10.1055/s-2004-814329.View ArticlePubMed
- Peterson Hm, McCole D, Auld CD: Impact of open-access endoscopy on detection of earlyoesophageal and gastric cancer 1994-2003: population-based study. Endoscopy. 2006, 38: 503-7. 10.1055/s-2006-925124.View Article
- Meineche-Schmidt V, Jorgensen T: « Alarm symptoms » in patients with dyspepsia: a threeyearprospective study from general practice. Scand J Gastroenterol. 2002, 37: 999-1007. 10.1080/003655202320378167.View ArticlePubMed
- Vakil N: Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: systematic review and meta-analysis. Gastroenterology. 2006, 131: 390-401. 10.1053/j.gastro.2006.04.029.View ArticlePubMed
- Lassen A, Hallas J, De Muckadell OBS: The risk of missed gastroesophageal cancer diagnosesin users and nonusers of antisecretory medication. Gastroenterology. 2005, 129: 1179-86. 10.1053/j.gastro.2005.07.028.View ArticlePubMed
- O'Malley PG, Wong PW, Kroenke K, Roy MJ, Wong RK: The value of screening forpsychiatric disorders prior to upper endoscopy. J Psychosom Res. 1998, 44: 279-87. 10.1016/S0022-3999(97)00250-X.View ArticlePubMed
- Hampton JR, Barlow AR: Open access. BMJ. 1995, 310: 611-2. 10.1136/bmj.310.6980.611.PubMed CentralView ArticlePubMed
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.