Table 3 Study vs. literature rates for penicillin allergy, cross reactivity, and cephalosporin allergy
Group | Our rate | Literature | P-value | Reference source |
|---|---|---|---|---|
Penicillin allergy | 703/5433 = 12.9% | High 295/1893 = 15.6% | P = 0.07 | 20. Lee CE, Arch Intern Med 2000;160:2819–22 |
Low 1821/3643 = 5.0% | P < 0.0001 | 8. Borch JE., Basic & Clinical pharmacology & Toxicology 2006; 98:357–362 | ||
Cross reaction of penicillin and cephalosporin | 4/265 = 1.5% with cefazolin | Old high 2/11 = 18.2% with cephalothin | P = 0.02 | 7. Thoburn R, JAMA 1966;198:345 |
Old low 3/74 = 4.1% with cefazolin | P = 0.18 | 4. Petz LD. J Infect Dis 1978;137(Suppl):S74-S9 | ||
New high 1/41 = 2.4% with cephalosporin | P = 0.52 | 55. Novalbos A, Clin Exp Allergy 2001;31: 438–43 | ||
New low 1/606 = 0.2% with cephalosporin | P = 0.03 | 49. Daulat S, J Allergy Clin Immunol 2004;113: 1220–2 | ||
Cephalosporin allergy | 12/2873 = 0.4% | High 10/473 = 2.1% | P < 0.0001 | Bigby M, JAMA. 1986; 256(24):3358–3363 |
Low 7035/949323 = 0.7% | P < 0.05 | Macy E, J Allergy Clin Immunol 2015;135: 745–752.e5 |