Table 1 Preoperative laboratory tests in patients undergoing major surgical resections classified by intra- and postoperative ABT requirements
Parameters preoperatively (median, quartiles [1st; 3rd]) | Control group (no ABT) n = 469 | ABT group n = 60 | p value |
|---|---|---|---|
Blood counts | |||
Leukocytes (/nL) | 7.80 [6.45; 9.30] | 8.65 [6.90; 10.33] | 0.0736 |
Erythrocytes (/pL) | 4.60 [4.30; 4.90] | 3.90 [3.50; 4.20] | < 0.0001 |
Hemoglobin (g/dL) | 14.0 [13.0; 14.9] | 10.9 [10.3; 12.3] | < 0.0001 |
Hematocrit (%) | 0.41 [0.39; 0.44] | 0.34 [0.31; 0.37] | < 0.0001 |
MCV (fL) | 90.0 [87.0; 93.0] | 88.0 [83.3; 92.0] | 0.0226 |
MCH (pg/cell) | 30.3 [29.2; 31.4] | 28.9 [27.5; 31.0] | < 0.0001 |
MCHC (g/dL) | 33.8 [33.0; 34.4] | 32.8 [32.1; 33.4] | < 0.0001 |
Thrombocytes (/nL) | 269.0 [223.0; 313.5] | 324.5 [236.3; 445.3] | < 0.0001 |
Blood coagulation | |||
INR | 1.02 [0.97; 1.07] | 1.07 [1.02; 1.14] | < 0.0001 |
PTT (s) | 30.0 [28.0; 32.0] | 30.05 [28.00; 33.10] | 0.3096 |
Fibrinogen (mg/dL) | 295.5 [250.0; 373.0] | 427.0 [294.0; 526.0] | < 0.0001 |
Clinical chemistry | |||
CRP (mg/L) | 3.30 [1.70; 8.80] | 14.50 [4.13; 64.40] | < 0.0001 |
Creatinine (ng/mL) | 1.0 [0.80; 1.10] | 1.0 [0.80; 1.10] | 0.3744 |
Urea (mg/dL) | 31.0 [24.0; 38.0] | 31.5 [24.3; 43.8] | 0.2857 |
eGFR (mL/min) > 60 (n, %) | 376/469 (80.2%) | 43/60 (71.7%) | 0.1264 |
ALAT (IU/L) | 27.0 [21.5; 37.0] | 23.0 [17.0; 32.0] | 0.0027 |
ASAT (IU/L) | 20.0 [16.0; 25.0] | 20.0 [16.3; 25.8] | 0.8248 |
GGT (IU/L) | 33.0 [25.0; 50.0] | 37.5 [27.3; 74.8] | 0.0845 |
LDH (IU/L) | 193.0 [170.8; 222.0] | 199.5 [163.0; 252.0] | 0.4550 |
Serum tumor markers | |||
CEA (ng/mL) | 3.20 [1.88; 5.83] | 3.00 [1.98; 7.30] | 0.7046 |
CYFRA 21-1 (ng/mL) | 1.70 [1.20; 2.70] | 2.35 [1.40; 4.58] | 0.0026 |
NSE (ng/mL) | 17.35 [14.60; 20.83] | 17.40 [14.65; 23.63] | 0.7439 |