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Table 2 Cox PHs analysis showing the association of variables with prognosis in the primary cohort

From: Development and validation of a nomogram for survival prediction in hepatocellular carcinoma after partial hepatectomy

Variable

Univariate analysis

HR (95% CI)

P value

Multivariate analysis

HR (95% CI)

P value

Age

0.943 (0.821–1.084)

0.412

  

Race

 White

Reference

   

 Black

1.347 (0.959–1.892)

0.086

  

 Other

0.791 (0.591–1.059)

0.115

  

Sex

 Male

Reference

   

 Female

1.329 (0.987–1.790)

0.061

  

Differentiation

 Well

0.644 (0.443–0.937)

0.022

0.849 (0.558–1.291)

0.443

 Moderately

Reference

 

Reference

 

 Poorly/undifferentiated

1.475 (1.104–1.972)

0.009

1.384 (1.017–1.885)

0.039

The extent of tumor

 Localized

Reference

 

Reference

 

 Regional

2.236 (1.666–3.000)

< 0.001

1.310 (0.839–2.044)

0.235

 Distant

3.966 (2.335–6.736)

< 0.001

0.716 (0.144–3.560)

0.683

AJCC staging

 I

Reference

 

Reference

 

 II

1.952 (1.452–2.624)

< 0.001

0.958 (0.213–4.312)

0.956

 III

2.942 (2.112–4.097)

< 0.001

2.000 (0.407–9.815)

0.393

 IV

5.218 (3.066–8.885)

< 0.001

1.527 (0.183–12.747)

0.696

T staging

 T1

Reference

 

Reference

 

 T2

2.024 (1.517–2.699)

< 0.001

1.294 (0.284–5.884)

0.739

 T3

2.561 (1.795–3.654)

< 0.001

0.698 (0.153–3.193)

0.643

 T4

5.785 (3.494–9.579)

< 0.001

1.449 (0.270–7.785)

0.665

N staging

 N0

Reference

   

 N1

2.130 (0.877–5.170)

0.095

  

M staging

 M0

Reference

 

Reference

0.176

 M1

4.947 (2.814–8.694)

< 0.001

5.000 (0.485–51.541)

Tumor size

 < 3 cm

0.912 (0.607–1.370)

0.657

0.991 (0.653–1.503)

0.965

 3–5 cm

Reference

 

Reference

 

 5–10 cm

1.398 (0.997–1.960)

0.052

1.340 (0.931–1.927)

0.115

 ≥ 10

2.349 (1.621–3.402)

 < 0.001

1.812 (1.179–2.786)

0.007

AFP

 Positive

Reference

 

Reference

0.022

 Normal

0.243 (0.139–0.424)

< 0.001

0.698 (0.514–0.950)

Fibrosis

 Normal

Reference

 

Reference

0.008

 Cirrhosis

1.341 (1.045–1.721)

0.021

1.473 (1.107–1.960)

MVI

 No

Reference

 

Reference

0.105

 Yes

1.921 (1.471–2.510)

< 0.001

1.447 (0.926–2.259)

Radiotherapy

 No

Reference

 

Reference

0.165

 Yes

1.819 (1.039–3.186)

0.038

1.557 (0.834–2.909)

Chemotherapy

 No

Reference

 

Reference

0.444

 Yes

1.621 (1.166–2.254)

0.004

1.163 (0.789–1.715)

  1. Other race: American Indian/AK Native, Asian/Pacific Islander
  2. AFP the highest AFP test results documented in the medical record prior to treatment, MVI microvascular invasion
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