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Table 3 Univariable and multivariable Cox regression analysis for recurrence-free survival (n = 503)

From: Perioperative pectoral nerve block type II and postoperative recurrence in breast cancer: a randomized controlled trial

 

Unadjusted

Adjusted

HR (95% CI)

P value

HR (95% CI)

P value

Age (years)

    

 < 40

1 (ref)

 

1 (ref)

 

40–49

0.81 (0.51–1.16)

0.177

0.96 (0.69–1.28)

0.476

50–59

0.67 (0.49–0.93)

0.228

0.74 (0.52–1.06)

0.137

 ≥ 60

0.59 (0.38–0.86)

0.039

0.61 (0.41–1.02)

0.062

ASA physical status

    

I

1 (ref)

 

1 (ref)

 

II

1.19 (0.88–1.36)

0.571

1.23 (0.93–1.44)

0.274

III

1.89 (1.11–3.24)

0.035

2.14 (1.05–3.63)

0.042

TNM stage

    

1

1 (ref)

 

1 (ref)

 

2 + 3

3.72 (2.18–5.65)

 < 0.001

3.48 (1.96–5.47)

0.009

Surgery type

    

Breast conservation

1 (ref)

 

1 (ref)

 

Mastectomy

2.11 (1.48–2.81)

0.028

1.77 (1.21–2.36)

0.041

Oestrogen receptor

    

Negative

1 (ref)

 

1 (ref)

 

Positive

0.62 (0.48–0.81)

0.068

0.77 (0.51–1.25)

0.236

Progesterone receptor

    

Negative

1 (ref)

 

1 (ref)

 

Positive

0.59 (0.46–0.77)

0.055

0.92 (0.69–1.25)

0.526

HER2

    

Negative

1 (ref)

 

1 (ref)

 

Positive

1.37 (0.88–2.04)

0.114

1.22 (0.80–1.83)

0.331

  1. ASA, American Society of Anesthesiologists; TNM, tumor–node–metastasis; HER2, human epidermal growth factor 2
  2. HRs in multivariate analysis were adjusted for age, ASA physical status, TNM stage, surgery type, oestrogen status, progesterone status, and HER2 status