Table 2 Outcomes for central and extended hepatectomy for hepatocellular carcinoma
Outcomes | Studies (n) | Patients (n) | Effect estimate [RR/MD (95% CI)] | Heterogeneity | Test for overall effect | Favour group |
|---|---|---|---|---|---|---|
Overall survival | Â | Â | Â | Â | Â | Â |
 1-year | 8 | 1634 | 1.00 [0.96, 1.04] | I2 = 16% (P = 0.31) | Z = 0.10 (P = 0.92) | None |
 2-year | 6 | 855 | 1.14 [1.06, 1.23] | I2 = 21% (P = 0.27) | Z = 3.46 (P = 0.0005) | CH |
 3-year | 7 | 1530 | 1.13 [0.97, 1.33] | I2 = 71% (P = 0.002) | Z = 1.56 (P = 0.12) | None |
 4-year | 5 | 765 | 1.31 [1.16, 1.48] | I2 = 6% (P = 0.36) | Z = 4.38 (P < 0.0001) | CH |
 5-year | 7 | 1565 | 1.14 [0.96, 1.35] | I2 = 56% (P = 0.03) | Z = 1.54 (P = 0.12) | None |
Disease free survival | Â | Â | Â | Â | Â | |
 1-year | 8 | 1605 | 1.03 [0.92, 1.15] | I2 = 50% (P = 0.05) | Z = 0.49 (P = 0.63) | |
 2-year | 5 | 765 | 1.04 [0.90, 1.20] | I2 = 29% (P = 0.23) | Z = 0.48 (P = 0.63) | |
 3-year | 7 | 1447 | 1.19 [0.91, 1.56] | I2 = 74% (P = 0.0007) | Z = 1.26 (P = 0.21) | |
 4-year | 5 | 765 | 0.92 [0.75, 1.13] | I2 = 37% (P = 0.18) | Z = 0.79 (P = 0.43) | |
 5-year | 7 | 1565 | 0.81 [0.61, 1.08] | I2 = 60% (P = 0.02) | Z = 1.43 (P = 0.15) | |
Recurrence | 4 | 1081 | 1.04 [0.94, 1.15] | I2 = 27% (P = 0.25) | Z = 0.76 (P = 0.45) | |
Mortality | 8 | 1626 | 0.55 [0.26, 1.15] | I2 = 0% (P = 0.91) | Z = 1.58 (P = 0.11) | |
Complications | Â | Â | Â | Â | Â | |
 Overall | 7 | 1270 | 0.94 [0.76, 1.16] | I2 = 0% (P = 0.48) | Z = 0.57 (P = 0.57) | |
 Liver cell failure | 6 | 1415 | 0.47 [0.30, 0.76] | I2 = 0% (P = 0.52) | Z = 3.10 (P = 0.002) | CH |
 Biliary fistula | 7 | 1455 | 1.90 [1.07, 3.40] | I2 = 0% (P = 0.85) | Z = 2.18 (P = 0.03) | EH |
 Ascites | 4 | 1084 | 1.95 [1.00, 3.78] | I2 = 0% (P = 0.88) | Z = 1.97 (P = 0.05) | None |
 Wound infection | 5 | 1282 | 0.77 [0.39, 1.52] | I2 = 0% (P = 0.79) | Z = 0.76 (P = 0.44) | |
Operative details | Â | Â | Â | Â | Â | |
 Time of the operation | 4 | 328 | 0.82 [0.36, 1.27] | I2 = 57% (P = 0.07) | Z = 3.53 (P = 0.0004) | |
 Blood loss | 3 | 280 | 40.87 [− 8.81, 90.54] | I2 = 13% (P = 0.32) | Z = 1.61 (P = 0.11) | |
 blood transfusion | 3 | 224 | 269.54 [− 169.28, 708.35] | I2 = 78% (P = 0.01) | Z = 1.20 (P = 0.23) | |
 Hospital stay | 3 | 280 | − 2.17 [− 5.56, 1.22] | I2 = 83% (P = 0.003) | Z = 1.25 (P = 0.21) |