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Table 1 Basic data of the included studies

From: Central hepatectomy versus major hepatectomy for patients with centrally located hepatocellular carcinoma: a systematic review and meta-analysis

Author and Publication year

Country

Study design

Study period

Arm

Sample size (n)

Age (yr)

Gender: M/F(n)

Child score(A/B/C)

Virology (HBV/HCV/Both)

Cirrhosis (n/%)

ICG-R15 (%)

Tumor size (cm)

Tumor number (S/M)

Vascular invasion (%)

Resection margin (< 1 cm/ > 1 cm)

Wu, 1999 [15]

Taiwan

Retrospective Cohort

1987–1997

CH

15

53.0 ± 11.6 a

15/0

14/1/0

13/2/0

11–

N/A

12.8

N/A

N/A

N/A

EH

25

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Hu, 2003 [12]

Taiwan

Cohort

1993–1999

CH

52

N/A

N/A

N/A

24(HCV)

24

17.4 ± 1.5a

 < 9

47/5

12

22/30

EH

63

N/A

N/A

N/A

13(HCV)

24

12.4 ± 2.2a

 < 9

50/13

26

16/47

Cheng, 2012 [16]

Taiwan

Cohort

1999–2005

CH

63

58(50–66)b

50/13

56/7/0

43/13/0

30 (47.6%)

8.57 (5.20–13.53)b

6.50 (5.50–8.50)b

N/A

30 (47.6%)

50//4

EH

41

61(50–68.5)b

32/9

37/3/0

27/8/0

15 (36.6%)

8.14 (5.88–14.48)b

8.00 (5.50–10.25)b

N/A

19 (46.3%)

30//8

Chen, 2014 [17]

China

Cohort

2002–2008

CH

118

56.4 ± 12.3a

96/22

6.7 ± 1.2

100/15/0

106

5.3 ± 2.0

8.6 ± 2.4

N/A

30

39/79

EH

80

N/A

67/13

N/A

69/10/0

68

N/A

N/A

N/A

24

13/67

Yang, 2014 [18]

China

Retrospective Cohort

2002–2012

CH

350

N/A

298/52

298/52/0

315 (HBV)

281

N/A

N/A

161/189

195

144/206

EH

346

47.5 ± 11.8a

289/57

284/62/0

303 (HBV)

272

N/A

8.1 ± 5.3a

141/205

194

133/213

Chinburen, 2015 [19]

Mongolia

Retrospective Cohort

2003–2012

CH

45

59.8 ± 8.5a

23/22

30/0/0

14/21/0

N/A

N/A

5.9 ± 2.2a

37/8

N/A

N/A

EH

24

55.4 ± 9.2 a

12//12

14/1/0

8/7//0

N/A

N/A

7.2 ± 2.1 a

21/3

N/A

N/A

Chen, 2017 [20]

Taiwan

Retrospective Cohort

2007–2010

CH

15

62 ± 14a

12//3

N/A

10/3//1

3

8.94 ± 5.08a

4.71 ± 2.25a

N/A

5

N/A

MH

33

60 ± 13a

22/11

N/A

18//5//2

15

8.34 ± 4.31a

5.28 ± 4.17a

N/A

15

N/A

Li, 2018 [13]

China

Retrospective Cohort

200–2016

CH

87

53.0 ± 7.8a

63/24

N/A

74 (HBV)

80

7.3 ± 1.9a

4.2 ± 0.9a

N/A

10 (11.5%)

N/A

MH

84

54.4 ± 9.2a

66/18

N/A

70 (HBV)

67

7.3 ± 2.3a

4.1 ± 1.0 a

N/A

10 (11.9%)

N/A

Orimo, 2021 [21]

Japan

Retrospective Cohort

200–2019

CH

132

68 (39–86)b

112/20

N/A

40/39/0

N/A

11.6 (2.9–86.7)b

4.5 (1.2–15.2)b

91/41

N/A

N/A

MH

101

65 (33–85) b

85/16

N/A

45/22/0

N/A

10.8 (1.4–54.0)b

6.5 (0.6–22.5) b

65/36

N/A

N/A

  1. aThe results are presented as means and standard deviation
  2. bThe results are presented as median and range
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