Table 4 Prognostic factors of OS in recurrent DCC by univariate and multivariate analyses
Factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR | p-value | HR (95% CI) | p-value | |
Age (> 73) | 0.90 | 0.736 |  |  |
Sex (Female) | 0.93 | 0.875 | Â | Â |
CEA (> 5.0 ng/ml) | 1.00 | 0.987 |  |  |
CA19-9 (> 71.5 U/ml) | 0.82 | 0.525 |  |  |
Operation time (> 306 min) | 1.19 | 0.559 |  |  |
Blood loss (> 844 ml) | 0.68 | 0.209 |  |  |
Blood transfusion (Yes) | 1.32 | 0.378 | Â | Â |
Clavien–Dindo classification (≥ 3a) | 0.99 | 0.963 |  |  |
Tumour Size (> 28 mm) | 2.21 | 0.008 |  |  |
Gross tumour type (Nodular/Flat) | 2.59 | 0.048 | Â | Â |
Pancreatic invasion (positive) | 1.62 | 0.116 | Â | Â |
Duodenal invasion (positive) | 0.98 | 0.883 | Â | Â |
Portal vein invasion (positive) | 1.93 | 0.215 | Â | Â |
Lymphovessel invasion (positive) | 1.45 | 0.317 | Â | Â |
Venous invasion (positive) | 1.93 | 0.055 | Â | Â |
Perineural invasion (positive) | 2.32 | 0.163 | Â | Â |
R1 resection | 1.77 | 0.062 | Â | Â |
Tumour differentiation (moderate/poor/others) | 1.38 | 0.268 | Â | Â |
pT3 | 2.25 | 0.019 | Â | Â |
Lymph node metastasis (positive) | 1.46 | 0.200 | Â | Â |
Adjuvant chemotherapy (No) | 0.58 | 0.077 | Â | Â |
Time to recurrence (≤ 12 months) | 11.56 |  < 0.001 | 16.4 (0.52–41.4) | < 0.001 |
Resection of recurrent lesions (Yes) | 0.30 | 0.023 | 0.29 (0.1–0.9) | 0.025 |