Table 2 Univariable and multivariable analysis for OS and DFS among all IGC patients (n = 102) with definitive surgical treatment
From: Residual cancer is a strong predictor of survival in T3 incidental gallbladder cancer
Risk factor | OS | DFS | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Age (≥ 60 years) | 1.477 (0.844–2.585) | 0.172 | 1.425 (0.859–2.346) | 0.171 | ||||
CA19-9 (≥ 39 U/mL) | 2.615 (1.433–4.739) | 0.002 | 2.114 (1.041–4.292) | 0.038 | 2.311 (1.323–4.038) | 0.003 | 1.402 (0.768–2.559) | 0.271 |
Residual cancer (Absent vs. Present) | 4.650 (2.647–8.171) | < 0.001 | 3.347 (1.439–7.785) | 0.005 | 3.440 (2.048–5.779) | < 0.001 | 3.615 (1.572–8.314) | 0.002 |
Tumour location (vs. Peritoneal side) | < 0.001 | 0.119 | 0.001 | 0.132 | ||||
Hepatic side | 2.388 (1.302–4.382) | 0.005 | 0.566 (0.211–1.523) | 0.260 | 2.152 (1.227–3.772) | 0.007 | 0.495 (0.199–1.231) | 0.130 |
Both sides | 9.429 (3.113–28.559) | < 0.001 | 2.559 (0.638–10.260) | 0.185 | 6.204 (1.849–20.816) | 0.003 | 1.431 (0.353–5.800) | 0.616 |
Intraoperative blood transfusion (Absent vs. Present) | 2.346 (1.175–4.685) | 0.016 | 3.068 (1.274–7.389) | 0.012 | 1.915 (0.906–4.049) | 0.089 | 2.396 (1.046–5.492) | 0.039 |
R1 resection and/or peri neural and/or lymphovascular invasion (Absent vs. Present) | 2.792 (1.343–5.805) | 0.006 | 0.905 (0.322–2.542) | 0.849 | 1.693 (0.674–4.256) | 0.263 | ||
Lymph node (Negative vs. Positive) | 3.440 (1.957–6.047) | < 0.001 | 2.783 (1.503–5.156) | 0.001 | 3.175 (1.898–5.310) | < 0.001 | 3.316 (1.784–5.601) | < 0.001 |
Differentiation grade (High/Intermediate vs. Low) | 2.280 (1.261–4.123) | 0.006 | 1.946 (0.948–3.993) | 0.070 | 1.467 (0.827–2.602) | 0.190 | ||