Table 1 Comparison of Clinicopathologic Variables between Patients with RC− versus RC +
From: Residual cancer is a strong predictor of survival in T3 incidental gallbladder cancer
Characteristics | All (n = 102) | RC + (n = 32) | RC− (n = 70) | P value |
|---|---|---|---|---|
Sex, n (%) | ||||
Male | 43 (42.2) | 15 (46.9) | 28 (40.0) | 0.514 |
Female | 59 (57.8) | 17 (53.1) | 42 (60.0) | |
Age, mean ± SD, year | 59 ± 11 | 61 ± 9 | 59 ± 11 | 0.271 |
CA19-9, median (IQR), U/ml | 12.4 (6.8–40.1) | 36.3 (7.2–212.9) | 11.8 (6.7–20.7) | 0.027 |
First cholecystectomy procedure | ||||
Extended cholecystectomy | 33 (32.4) | 5 (15.6) | 28 (40.0) | 0.022 |
Simple cholecystectomy | 69 (67.6) | 27 (84.4) | 42 (60.0) | |
Tumour location*, n (%) | ||||
Peritoneal side | 76 (74.5) | 6 (18.8) | 70 (100) | < 0.001 |
Hepatic side | 23 (22.5) | 23 (71.9) | 0 | |
Both sides | 3 (2.9) | 3 (9.4) | 0 | |
Surgical approach, n (%) | ||||
Radical resection | 93 (91.2) | 28 (87.5) | 65 (92.9) | 0.456 |
Extended resection | 9 (8.8) | 4 (12.5) | 5 (7.1) | |
Operation duration, mean ± SD, h | 3.5 (3.0–4.0) | 4.0 (3.5–4.5) | 3.5 (3.0–4.0) | 0.090 |
Intraoperative blood loss, median (IQR), ml | 300 (200–400) | 300 (200–450) | 300 (188–400) | 0.166 |
Surgical Margin | ||||
Positive | 3 (2.9) | 3 (9.4) | 0 | 0.029 |
Negative | 99 (97.1) | 29 (90.6) | 70 (100) | |
Peripheral neurovascular invasion, n (%) | 11 (9.8) | 6 (18.8) | 5 (7.1) | 0.079 |
No. of positive lymph node, median (IQR) | 2 (1–4) | 2 (1–4) | 2 (1–3) | 0.682 |
No. of harvested lymph node, median (IQR) | 5 (4–8) | 6 (3–9) | 5 (4–7) | 0.166 |
Tumour differentiation grade, n (%) | ||||
Well | 8 (7.9) | 4 (12.1) | 4 (5.7) | 0.010 |
Moderately | 69 (67.7) | 15 (46.9) | 54 (77.1) | |
Poorly | 25 (24.5) | 13 (40.6) | 12 (17.1) | |
Lymph node status | ||||
Negative | 69 (67.6) | 17 (53.1) | 52 (74.3) | 0.034 |
Positive | 33 (32.4) | 15 (46.9) | 18 (25.7) | |
TNM Group of AJCC 8th*, n (%) | ||||
IIIA | 69 (67.6) | 17 (53.1) | 52 (74.3) | 0.079 |
IIIB | 24 (23.5) | 10 (31.3) | 14 (20.0) | |
IVB | 9 (8.8) | 5 (15.6) | 4 (5.7) | |
Adjuvant chemoradiotherapy | ||||
Have | 22 (21.6) | 6 (18.8) | 16 (22.9) | 0.640 |
None | 80 (78.4) | 26 (81.3) | 54 (77.1) | |
Postoperative major complications*, n (%) | 8 (7.8) | 5 (15.6) | 3 (4.3) | 0.104 |
Postoperative hospital stay, mean ± SD, d | 10 (8–12) | 11 (9–15) | 10 (7–11) | 0.034 |