Table 2 Treatment continuation and subsequent wound closure outcome after hospital discharge in the PP population

Study participants with inpatient study start, No. (%)^*

144 of 157 (91.7)

155 of 174 (89.1)

Study participants treated exclusively inpatient, No. (%)^*

17 of 144 (11.8)

7 of 155 (4.5)

Study participants with surgical wound closure before first hospital discharge, No. (%)

36 of 144 (25.0)

17 of 155 (11.0)

Study participants with hospital discharge, No. (%)^*

127 of 144 (88.2)

148 of 155 (95.5)

Study participants with completed treatment before first hospital discharge (including those with wound closure), No. (%)

46 of 144 (1.9)

26 of 155 (16.8)

Study participants with completed treatment before first hospital discharge and complete, verified and sustained wound closure within 42 days, No. (%)

40 of 46 (87.0)

21 of 26 (80.8)

Time to complete, sustained and verified wound closure (days) within 42 days for study participants with completed treatment before first hospital discharge, Mean (SE) [95% CI]

26.3 (1.0) [24.2–28.3]

29.9 (1.5) [26.8–33.0]

Study participants under treatment at first hospital discharge, No. (%)^*

81 of 144 (56.3)

122 of 155 (78.7)

Study participants with treatment termination at day of first hospital discharge, No. (%)^*

0

1

Treatment status at first hospital discharge and continuation of the respective treatment during outpatient care in the PP population

NPWT

CWT after NPWT

NPWT

CWT

Study participants in the outpatient subpopulation, No. (%)

55 of 157 (35.0)

26 of 157 (16.6)

0 of 174

(0)

121 of 174 (69.5)

Total treatment time until complete, sustained and verified wound closure or end of study treatment time after 42 days, Mean (SD) [Min–Max]

25.2 (13.1)

[6–42]

34.3 (9.2)

[16–42]

NA

34.4 (11.1)

[7–42]

Outpatient treatment time until complete, sustained and verified wound closure or end of study treatment time after 42 days, Mean (SD) [Min–Max]

17.1 (11.5)

[0–39]

16.1 (9.8)

[1–33]

NA

23.1 (11.7)

[0–40]

Study participants with rehospitalization, No. (%)

8 of 55 (14.5%)

6 of 26

(23.1%)

NA

13 of 121

(10.7%)

Study participants with complete, verified and sustained wound closure within 42 days, No. (%)

27 of 55 (49.1)

8 of 26 (30.8)

NA

27 of 121 (22.3)

Time to complete, sustained and verified wound closure (days) within 42 days, Mean (SE) [95% CI]

28.8 (8.0) [25.6–32.0]

28.9 (9.5)

[20.9–36.8]

NA

30.4 (8.0)

[27.3–33.6]

Study participants still under treatment at day 42, No. (%)

7 of 157 (4.5%)

38 of 157 (24.2%)

NA

85 of 174 (48.9%)

 Study participants still under treatment in hospital at day 42, No. (%)

2 of 7 (28.6%)

6 of 38 (15.8%)

NA

8 of 85 (9.4%)

 Study participants still under treatment in outpatient care at day 42 No. (%)

5 of 7 (71.4%)

32 of 38 (84.2%)

NA

77 of 85 (90.6%)

Study participants with wound closure within 132 days, No. (%)

47 of 55 (85.5)

21 of 26 (80.8)

NA

98 of 121 (81.0)

Time to wound closure (days) within 132 days, Mean (SE) [95% CI]

42.4 (3.3)

[35.8–48.9]

54.7 (7.0)

[40.2–69.3]

NA

56.3 (2.6)

[51.1–61.5]