Table 3 Univariate and multivariate analyses of clinicopathological parameters for PFS
Factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
P | HR (95% CL) | P | HR (95% CL) | |
Sex | ||||
Female | – | Reference | ||
Male | 0.551 | 1.419 (0.450–4.477) | NA | NA |
Age | ||||
≤ 45 | – | Reference | – | Reference |
> 45 | 0.035 | 3.218 (1.089–9.509) | 0.476 | 1.529 (0.475–4.916) |
Histology | ||||
Typical carcinoids | – | Reference | ||
Atypical carcinoids | 0.111 | 2.323 (0.824–6.545) | NA | NA |
Nodes metastases | ||||
N1 positive, n (%) | – | Reference | ||
N2 positive, n (%) | 0.829 | 0.894 (0.324–2.470) | NA | NA |
Ki-67 | ||||
Ki-67 ≤ 4.5 | – | Reference | – | Reference |
Ki-67 > 4.5 | 0.002 | 10.050 (2.254–44.802) | 0.060 | 4.711 (0.937–23.678) |
Chemotherapy | ||||
No | – | Reference | – | Reference |
Yes | 0.034 | 3.453 (1.099–10.850) | 0.977 | 1.019 (0.281–3.692) |
Tumor size | ||||
Size ≤ 2.4 cm | – | Reference | – | Reference |
Size > 2.4 cm | 0.005 | 8.626 (1.836–38.425) | 0.559 | 2.002 (0.195–20.594) |
EAS syndrome | ||||
No | – | Reference | – | Reference |
Yes | 0.002 | 0.096 (0.021–0.426) | 0.047 | 0.196 (0.039–0.982) |