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Table 2 Univariable and multivariable analysis for recurrence free survival (RFS) in 124 patients

From: The outcomes and prognostic factors of patients who underwent reoperation for persistent/recurrent papillary thyroid carcinoma

Variables

Univariable analysis

Multivariable analysis

P value

HR (95%CI)

P value

HR (95%CI)

Gender

 Male

0.954

0.979(0.478–2.007)

  

 Female

 

1

  

Age at reoperation*

 > 55

0.003

3.103 (1.487–6.477)

0.297

1.528 (0.689–3.392)

 ≤ 55

 

1

 

1

Post-reop unstim-Tg (ng/mL)*

 > 10.1

0

11.135 (5.14–24.122)

0.001

4.597 (1.881–11.233)

 ≤ 10.1

 

1

 

1

Time span between initial surgery and reoperation (months)*

 > 23

0

6.003 (2.93–12.298)

0.213

1.797 (0.714–4.522)

 ≤ 23

 

1

 

1

Frequency of pre-reop RAI therapy*

 > 3 times

0.001

3.371 (1.678–6.771)

0.376

0.472 (0.09–2.484)

 ≤ 3 times

 

1

  

Dose of pre-reop RAI therapy (mCi)*

 > 440

0

5.305 (2.641–10.656)

0.204

2.742 (0.579–12.983)

 ≤ 440

 

1

 

1

RAI-avidity character

 

0.58

   

 RAI-Avid

0.297

1.471 (0.712–3.041)

  

 Unknown

0.737

1.294 (0.289–5.802)

  

 RAI-refractory

 

1

  

Metastatic lymph node with extranodal extension

 Yes

0

9.096 (4.049–20.435)

0.023

3.129 (1.167–8.392)

 No

 

1

 

1

  1. All P values < 0.05 are shown in bold
  2. *The cutoff value of age, unstim-Tg level, time span between initial surgery and reoperation, frequency and dose of RAI therapies were determined by X-tile program
  3. HR hazard ratio, CI confidence interval, RAI radioiodine