Fig. 2

Picture collage showing benign mimickers of the carcinoma gall bladder. a–d IgG4 Cholecystitis. a Contrast-enhanced computed tomogram (CECT) of the abdomen shows irregular heterogeneously enhancing thickened gall bladder wall forming a mass with loss of interface with liver (Yellow arrow). b Resected specimen showing irregular thickened gall bladder infiltrating the liver bed (yellow arrow). c Photomicrograph (400×) reveals dense infiltration with plasma cells and lymphocytes. These plasma cells have eccentrically placed cartwheel-like nuclei with perinuclear hof. d Immunohistochemistry image shows characteristics cell with strong cytoplasmic positivity for IgG4. e–g Xanthogranulomatous Cholecystitis: e CECT of the abdomen shows irregular hypodense thickened gall bladder wall forming a mass with loss of interface with liver (Yellow arrow). f Resected specimen showing irregular thickened gall bladder wall (yellow arrow). g Photomicrograph (40×) reveals Aschoff-Rokitansky sinus (thick yellow arrow), thickened gallbladder wall with myofibroblastic proliferation (black arrow) with infiltrates of lympho-histiocytes and chronic inflammatory cells (thin yellow arrow). h–j Gall bladder tuberculosis: h CECT of the abdomen shows irregular heterogeneously enhancing thickened gall bladder wall with loss of interface with liver (Yellow arrow). i Specimen showing multi-visceral resection including gall bladder mass (yellow arrow) with a colon (black arrow) and omentum. j Photomicrograph (40×) reveals granulomas with caseous necrosis (yellow arrowhead) and multinucleated giant cells (black arrow)