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Table 3 Independent risk factors for RFS and OS verified by univariate and multivariate analyses

From: Novel postoperative nomograms for predicting individual prognoses of hepatitis B-related hepatocellular carcinoma with cirrhosis

Clinical parameters RFS OS
HR (95% CI) P-value HR (95% CI) P-value
Univariate analysis
SEX (male/female) 0.894 (0.596–1.210) 0.365 0.816 (0.537–1.238) 0.338
Age (≥ 60/< 60 years) 0.797 (0.600–1.06) 0.118 0.844 (0.608–1.170) 0.308
HBV-DNA (≥ 103/< 103 copies/mL) 1.433 (1.112–1.845) 0.005 1.566 (1.159–2.117) 0.004
HBeAg (positive/negative) 1.397 (1.067–1.830) 0.015 1.487 (1.094–2.021) 0.011
AFP (≤ 20/20–400/≥ 400 ng/mL) 1.801 (1.427–2.273) < 0.001 1.912 (1.463–2.497) < 0.001
WBC (≥ 4/< 4 × 109/L) 1.353 (0.957–1.913) 0.087 1.340 (0.900–1.995) 0.149
NEU (≥ 3.56/< 3.56 × 109/L) 1.310 (1.033–1.662) 0.026 1.529 (1.165–2.007) 0.002
LYM (≥ 1.1/< 1.1 × 109/L) 1.331 (1.005–1.763) 0.046 1.430 (1.027–1.992) 0.034
PLT (≥ 100/< 100 × 109/L) 1.205 (0.949–1.530) 0.126 1.424 (1.075–1.886) 0.014
PT (≥ 12.8/< 12.8 s) 0.953 (0.720–1.260) 0.735 0.929 (0.673–1.283) 0.656
INR (≥ 1.15/< 1.15) 0.897 (0.688–1.169) 0.421 0.923 (0.678–1.257) 0.611
Fib (≥ 2/< 2 g/L) 1.279 (0.930–1.761) 0.131 1.336 (0.904–1.997) 0.147
TB (≥ 28/< 28 μmol/L) 0.740 (0.447–1.226) 0.243 0.690 (0.376–1.265) 0.23
ALT (≥ 50/< 50 IU/L) 1.154 (0.912–1.458) 0.233 1.106 (0.843–1.452) 0.467
AST (≥ 40/< 40 IU/L) 1.255 (0.995–1.583) 0.055 1.391 (1.061–1.823) 0.017
ALB (≥ 40/< 40 g/L) 0.899 (0.708–1.141) 0.382 0.781 (0.594–1.026) 0.075
GGT (≥ 60/< 60 IU/L) 1.540 (1.220–1.943) < 0.001 2.027 (1.539–2.669) < 0.001
Child–pugh (A/B) 1.489 (0.663–3.344) 0.335 0.978 (0.367–2.655) 0.979
Tumor diameter 1.734 (1.370–2.195) < 0.001 1.960 (1.487–2.583) < 0.001
Tumor number (multiple/solitary) 1.543 (1.157–2.057) 0.003 1.217 (0.863–1.716) 0.263
Differentiation (III + IV/I + II) 1.300 (1.035–1.634) 0.024 1.653 (1.269–2.152) < 0.001
MVI (present/negative) 2.130 (1.689–2.687) < 0.001 2.529 (1.934–3.307) < 0.001
Satellite (present/negative) 1.906 (1.396–2.603) < 0.001 1.743 (1.217–2.496) 0.002
Anatomic hepatectomy (yes/no) 1.214 (0.961–1.534) 0.103 1.432 (1.095–1.873) 0.009
Blood loss (≥ 400/< 400 mL) 2.846 (0.860–9.415) 0.087 3.861 (0.902–16.529) 0.069
Transfusion (yes/no) 1.655 (0.819–3.346) 0.16 1.351 (0.600–3.043) 0.468
Multivariate analysis
HBeAg 1.423 (1.085–1.865) 0.011 1.528 (1.117–2.090) 0.008
AFP 1.546 (1.209–1.975) 0.001 1.417 (1.067–1.882) 0.016
Tumor diameter 1.038 (1.002–1.075) 0.041 1.054 (1.012–1.098) 0.012
MVI 1.906 (1.490–2.438) < 0.001 2.009 (1.507–2.677) < 0.001
Satellite lesion 1.791 (1.307–2.452) < 0.001 1.458 (1.015–2.093) 0.041
GGT ND ND 1.388 (1.025–1.879) 0.034
Differentiation ND ND 1.375 (1.044–1.810) 0.012
  1. Bold numbers indicate statistical significance
  2. RFS, recurrence-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; HBV-DNA, hepatitis B virus deoxyribonucleic acid; HBeAg, hepatitis B e antigen; AFP, alpha-fetoprotein; WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte; PLT, platelet; PT, prothrombin time; s, second; INR, international normalized ratio; Fib, fibrinogen; TBIL, total bilirubin; ALT, alanine transaminase; AST, aspartate aminotransferase; ALB, albumin; GGT, gamma-glutamyl transpeptidase; SD, standard deviation; MVI, microvascular invasion; ND, no data