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Table 2 The baseline characteristics of cirrhotic patients with HCC in training and validation cohort

From: Novel postoperative nomograms for predicting individual prognoses of hepatitis B-related hepatocellular carcinoma with cirrhosis

Clinical parameters Training cohort (n = 450, %) Validation cohort (n = 225, %) P-value
Gender, male 374 (86.2) 176 (81.1) 0.092
Age, ≥ 60 y 96 (22.2) 50 (23.0) 0.214
HBV-DNA, ≥ 103 copies/mL 246 (56.8) 137 (63.0) 0.367
HBeAg, positive 95 (21.9) 49 (22.6) 0.366
AFP, ≤ 20 ng/mL 173 (40.0) 83 (38.4) 0.866
AFP, 20–400 ng/mL 146 (33.7) 72 (33.3)
AFP, ≥ 400 ng/mL 114 (26.3) 61 (28.2)
WBC, ≥ 4 × 109/L 174 (40.0) 84 (38.5) 0.498
NEU, ≥ 3.56 × 109/L 156 (36.0) 74 (34.3) 0.657
LYM, ≥ 1.1 × 109/L 327 (75.3) 160 (73.6) 0.632
PLT, ≥ 100 × 109/L 266 (61.3) 132 (60.8) 0.909
PT, ≥ 12.8 s 125 (28.7) 55 (25.1) 0.388
INR, ≥ 1.15 115 (26.5) 51 (23.5) 0.408
Fib, ≥ 2 g/L 346 (79.6) 173 (79.9) 0.942
TB, ≥ 28 μmol/L 28 (6.5) 7 (3.2) 0.084
ALT, ≥ 50 IU/L 168 (38.7) 63 (29.0) 0.015
AST, ≥ 40 IU/L 229 (52.8) 93 (42.9) 0.017
ALB, ≥ 40 g/L 274 (63.1) 130 (59.9) 0.424
GGT, ≥ 60 IU/L 216 (49.8) 101 (46.5) 0.438
Child–pugh, Stage B 8 (1.8) 1 (0.5) 0.285
Tumor diameter, mean (SD), cm 5.65 (3.35) 5.28 (3.03) 0.178
Tumor number, multiple 73 (16.9) 36 (16.6) 0.931
Differentiation, III + IV 188 (43.4) 93 (42.9) 0.771
MVI, present 166 (38.2) 63 (29.0) 0.02
Satellite, present 56 (12.9) 24 (11.1) 0.493
Type of hepatectomy, anatomic 185 (42.7) 92 (42.3) 0.916
Blood loss, ≥ 400 mL 337 (86.8) 163 (75.0) 0.329
Transfusion, yes 67 (15.4) 38 (17.5) 0.523
  1. Bold numbers indicate statistical significance
  2. HBV-DNA, hepatitis B virus deoxyribonucleic acid; HBeAg, hepatitis B e antigen; AFP, alpha-fetoprotein; WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte; PLT, platelet; PT, prothrombin time; s, second; INR, international normalized ratio; Fib, fibrinogen; TBIL, total bilirubin; ALT, alanine transaminase; AST, aspartate aminotransferase; ALB, albumin; GGT, gamma-glutamyl transpeptidase; SD, standard deviation; MVI, microvascular invasion