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Table 3 Risk factors for lymph node metastasis

From: Evaluation of additional gastrectomy after noncurative endoscopic submucosal dissection for early gastric cancer

 

LNM Positive

LNM Negative

Univariate

Multivariate

 
 

(n = 14)

(n = 86)

P-value

OR (95% CI)           

P

Tumor size

     

   ≤ 30 mm

7

57

 

Reference

 

  > 30 mm

7

29

0.248

2.51 (0.58–10.80)

0.217

Depth of invasion

     

  M-SM1

0

20

   

  SM2 or deeper

14

66

0.066

NS

 

Histological type

     

  Differentiated

10

71

 

Reference

 

  Undifferentiated

4

15

0.460

8.39 (1.03–68.20)

0.047

Ulceration

     

  Negative

9

73

 

Reference

 

  Positive

5

13

0.125

3.97 (0.74–21.50)

0.109

Lymphatic invasion

     

  Negative

2

55

 

Reference

 

  Positive

12

31

 < 0.001

7.61 (1.15–50.30)

0.035

Vascular invasion

     

  Negative

7

71

 

Reference

 

  Positive

7

15

0.012

3.41 (0.73–15.90)

0.119

Horizontal margin

     

  Negative

13

81

   

  Positive

1

5

1.000

  

Vertical margin

     

  Negative

10

71

   

  Positive

4

15

0.460

  
  1. LNM lymph node metastasis, M confined to mucosa, SM1 depth of invasion from the muscularis mucosa < 500 µm
  2. SM2 depth of invasion from the muscularis mucosa ≥ 500 µm, OR odds ratio, CI confidence interval, NS not significant