Table 1 Summary of laboratory analysis and coagulation factor administration at different time point in this study
Date | Hemoglobin (g/L) | Platelet (109/L) | FVIII activity (%) | APTT (s) | D-dimer (mg/L FEU) | FIB (g/L) | Blood pressure (mmHg) | Volume of coagulation factor administration |
|---|---|---|---|---|---|---|---|---|
01/26/2021 (on admission) | 137 | 204 | 1.5 | 71.50 | 3.33 | 3.11 | 145/96 | – |
01/28/2021 (prior to surgery) | – | 223 | 50.4 | 43.90 | 4.48 | 2.94 | 112/63 | Bolus dose of 3500 IU + 1000 IU |
01/29/2021 (POD1) | 83 | 180 | 29.8 | 47.10 | 1.06 | 2.74 | 134/75 | Maintenance dose of 2000 IU q8h |
01/30/2021 (POD2: patient with slurred speech and decreased responsiveness) | 54 | 173 | 17.7 | 52.70 | 0.71 | 4.77 | 110/70 | Bolus dose of 4000 IU and maintenance dose of 4000 IU q8h |
01/30/2021 (after intravenous injection with RBC 2U and plasma 390 ml) | 62 | 176 | 43.5 | 40.60 | 0.66 | 4.53 | 115/72 | Maintenance dose of 4000 IU q8h |
01/31/2021 (POD4: patient with worsening alteration of consciousness) | 47 | 157 | 76.0 | 46.40 | 0.66 | 3.83 | 120/70 | Maintenance dose of 4000 IU q8h |
01/31/2021 (after intravenous injection with RBC 3U and plasma 350 ml) | 73 | 213 | 96.2 | 38.90 | 0.46 | 6.65 | 140/80 | Maintenance dose of 4000 IU q8h |