Table 1 Diagnosis criteria and severity classification of PPDC based on TG18
A. Systemic inflammation | ||
 A-1. Fever and/or shaking chills | ||
 A-2. Laboratory data: evidence of inflammatory response | ||
B. Cholestasis | ||
 B-1. Jaundice | ||
 B-2. Laboratory data: abnormal liver function tests | ||
C. Imaging | ||
 C-1. Biliary dilatation | ||
 C-2. Evidence of the etiology on imaging (stricture, stone, stent etc | ||
Suspected diagnosis: one item in A + one item in either B or C | ||
Definite diagnosis: one item in A, one item in B and one item in C | ||
Thresholds: | ||
A-1 | Fever | BT > 38 °C |
A-2 | Evidence of inflammatory response | WBC counts: < 4000 or > 10,000 /μL CRP: > 1.0 mg/dL |
B-1 | Jaudice | T-bil: > 2.0 mg/dL |
B-2 | Abnormal liver function | ALP, γ-GTP, AST, ALT: > 1.5 times the institutional standard values |
Severity classification and treatment | ||
|---|---|---|
Severity | General condition | Diagnosis criteria |
Mild | Not sick | Fever with mild laboratory abnormalities (cases that do not meet the criteria for moderate or severe cholangitis) |
Moderate | A little tight | Presenting with two of the following events: Age ≥ 75 BT ≥ 39 ºC WBC count < 4000 or 12,000 T-bil ≥ 5 mg/dl Serum albumin level 0.73 × the standard value |
Severe | Poor | Abnormalities suggestive of sepsis (associated with impairment of circulation, central nervous system, respiration, renal function, liver function, or coagulation) |