A prognostic nomogram for stage II/III rectal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgical resection

Table 2 Univariate and multivariate Cox analyses in II/III rectal cancer patients treated with NCRT followed by surgical resection

Variable	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P	HR	95% CI	P
Age
< 60	Reference			Reference
≥ 60	1.282	1.094–1.502	0.002**	1.344	1.145–1.579	< 0.001***
Race
Black	Reference			Reference
White	0.682	0.531–0.877	0.003**	0.666	0.517–0.858	0.002**
Other	0.719	0.522–0.900	0.044*	0.682	0.492–0.944	0.021*
Sex
Female	Reference			Reference
Male	1.282	1.094–1.502	0.002**	1.344	1.145–1.579	< 0.001***
Marital status
No	Reference			Reference
Yes	0.790	0.680–0.916	0.002**	0.829	0.711–0.966	0.016*
Grade
I	Reference			Reference
II	1.081	0.797–1.465	0.618	1.129	0.831–1.534	0.438
III	1.718	1.212–2.436	0.002**	1.567	1.098–2.235	0.013*
IV	1.891	1.038–3.446	0.037	1.815	0.985–3.343	0.056
T stage
T1	Reference			Reference
T2	1.312	0.455–3.783	0.615	1.481	0.507–4.331	0.473
T3	1.730	0.647–4.625	0.275	1.866	0.688–5.064	0.221
T4a	2.360	0.821–6.783	0.111	2.252	0.774–6.550	0.136
T4b	3.254	1.194–8.870	0.021*	3.141	1.136–8.681	0.027*
LODDS
< − 1.5	Reference			Reference
− 1.5 ~ − 0.4	1.660	1.355–2.034	< 0.001***	1.678	1.368–2.059	< 0.001***
≥ − 0.4	3.466	2.716–4.423	< 0.001***	3.616	2.820–4.637	< 0.001***
Tumor size (mm)
< 46	Reference			Reference
46–70	1.050	0.889–1.239	0.565	0.994	0.840–1.177	0.946
≥ 70	1.528	1.243–1.878	< 0.001***	1.309	1.056–1.623	0.014*
CEA level
Negative	Reference			Reference
Positive	1.567	1.351–1.817	< 0.001***	1.384	1.189–1.612	< 0.001***
Postoperative chemotherapy
No	Reference			Reference
Yes	0.797	0.685–0.928	0.003**	0.810	0.693–0.947	0.008**
Postoperative radiation
No	Reference
Yes	1.397	0.969–2.013	0.073

*P < 0.05; **P < 0.01; ***P < 0.001. NCRT neoadjuvant chemoradiotherapy, HR hazard ratio, CEA carcinoembryonic antigen, LODDS log odds of positive lymph nodes

ISSN: 1471-2482