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Table 2 Univariate logistic analysis on clinical parameters in predicting early recurrence in the training cohort

From: Preoperative and postoperative nomograms for predicting early recurrence of hepatocellular carcinoma without macrovascular invasion after curative resection

Clinical parameters

OR (95% CI)

P

Gender (male/female)

1.27 (1.043–1.545)

0.017

Age (> 60/ ≤ 60 years)

0.596 (0.480–0.740)

< 0.001

HBsAg (positive/negative)

1.262 (1.075–1.482)

0.004

HBV-DNA (≥ 103/< 103 copies/mL)

1.529 (1.164–2.010)

0.002

HBeAg (positive/negative)

1.771 (1.170–2.681)

0.007

AFP

  

 (< 20/20–400 ng/mL)

1.337 (1.171–1.527)

< 0.001

 (< 20/ > 400 ng/mL)

1.582(1.277–1.960)

< 0.001

NEU (> 3.56/ ≤ 3.56 × 109/L)

1.621 (1.241–2.117)

< 0.001

LYM (> 1.1/ ≤ 1.1 × 109/L)

1.221 (0.993–1.502)

0.059

PLT (> 100/ ≤ 100 × 109/L)

1.472 (1.189–1.821)

< 0.001

NLR (> 3/ ≤ 3)

2.000 (1.429–2.799)

< 0.001

PLR (> 111/ ≤ 111)

1.687 (1.247–2.282)

0.001

TB (> 28/ ≤ 28 μmol/L)

2.000 (0.684–5.581)

0.206

ALT (> 50/ ≤ 50 IU/L)

1.368 (1.000–1.870)

0.05

AST (> 40/ ≤ 40 IU/L)

1.602 (1.218–2.108)

0.001

ALB (> 40/ ≤ 40 g/L)

1.184 (0.947–1.482)

0.139

ALBI grade (1/2/3)

0.781 (0.523–1.168)

0.229

GGT (> 60/ ≤ 60 IU/L)

1.697 (1.306–2.205)

< 0.001

PT (> 12.8/ ≤ 12.8 s)

1.164 (0.812–1.668)

0.41

INR (> 1.15/ ≤ 1.15)

1.244 (0.841–1.842)

0.275

Fib (> 2/ ≤ 2 g/L)

1.079 (0.873–1.335)

0.482

Tumor size

  

 (≤ 5/5–10 cm)

3.279 (2.189–4.910)

< 0.001

 (≤ 5/ > 10 cm)

2.031 (1.497–2.755)

< 0.001

Tumor number

  

 (1/2)

2.295 (1.262–4.174)

0.007

 (1/3)

2.069 (1.193–3.588)

0.010

BCLC stage (A/B)

3.056 (1.795–5.203)

< 0.001

Cirrhosis (present/absent)

1.193 (0.949–1.499)

0.131

Differentiation (I + II/III + IV)

1.819 (1.365–2.426)

< 0.001

MVI (present/absent)

2.923 (2.133–4.005)

< 0.001

Satellite lesion (present/absent)

2.429 (1.461–4.037)

0.001

Resection (anatomic/non-anatomic)

1.475 (1.146–1.899)

0.003

  1. Bold numbers indicate statistical significance
  2. OR: odds ratio; CI: confidence interval; HBsAg: hepatitis B surface antigen; HBV-DNA: hepatitis B virus deoxyribonucleic acid; HBeAg: hepatitis B e antigen; AFP: alpha-fetoprotein; NEU: neutrophil; LYM: lymphocyte; PLT: platelet; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio; TBIL: total bilirubin; ALT: alanine transaminase; AST: aspartate aminotransferase; ALB: albumin; ALBI: albumin-bilirubin score; GGT: gamma-glutamyl transpeptidase; PT: prothrombin time; s: second; INR: international normalized ratio; Fib: fibrinogen; BCLC: Barcelona Clinic Liver Cancer staging system; MVI: microvascular invasion