Skip to main content

Table 3 Subgroup analysis of major bleeding in hospital (after IPTW)

From: Fondaparinux sodium and low molecular weight heparin for venous thromboembolism prophylaxis in Chinese patients with major orthopedic surgery or trauma: a real-world study

Items

FPX (N = 1177)

LMWH (N = 1252)

IPTW-weighted OR

P value

n/N (%)

n/N (%)

Age

 18–59 years

8/528 (1.5)

7/500 (1.4)

1.61 (0.57–4.61)

0.371

 ≥ 60 years

17/649 (2.6)

12/752 (1.6)

1.57 (0.74–3.34)

0.244

 60–79 years

9/518 (1.7)

10/656 (1.5)

1.12 (0.44–2.80)

0.815

 ≥ 80 years

8/131 (6.1)

2/96 (2.1)

2.52 (0.52–12.2)

0.254

 Weight ≤ 50 kg

6/125 (4.8)

1/135 (0.7)

5.16 (0.60–44.19)

0.135

Impairment of renal function

 Light

9/242 (3.7)

1/261 (0.4)

15.75 (1.97–126.14)

0.010

 Moderate

5/75 (6.7)

0/68 (0.0)

–

< 0.001

 Normal

7/541 (1.3)

14/469 (3.0)

0.57 (0.21–1.38)

0.229

Complication

 Diabetes mellitus

4/93 (4.3)

3/111 (2.7)

2.66 (0.56–12.67)

0.222

 Hypertension

8/402 (2.0)

7/451 (1.6)

1.65 (0.58–4.68)

0.350

 Tumor

0/35 (0.0)

1/32 (3.1)

–

< 0.001

 Anemia

7/69 (10.1)

2/49 (4.1)

4.44 (0.84–23.41)

0.081

Different types of surgerya

 Major orthopedic surgery

20/625 (3.2)

18/780 (2.3)

1.46 (0.75–2.83)

0.267

 Other trauma surgery

5/500 (1.0)

1/436 (0.2)

4.31 (0.50–37.32)

0.185

 No surgery

0/72 (0.0)

0/54 (0.0)

–

–

Different types of surgeryb

 Hip and knee replacement

16/456 (3.5)

15/654 (2.3)

1.57 (0.76–3.24)

0.225

 Trauma surgery

10/673 (1.5)

4/583 (0.7)

2.09 (0.65–6.72)

0.218

 No surgery

0/72 (0.0)

0/54 (0.0)

–

–

Premedicate

 > 0 h

11/476 (2.3)

5/337 (1.5)

1.69 (0.57–4.99)

0.343

 > 24 h

11/450 (2.4)

4/308 (1.3)

2.16 (0.66–7.06)

0.201

Different days of administration

 0–5 days

7/636 (1.1)

7/630 (1.1)

0.95 (0.33–2.76)

0.921

 6–9 days

16/376 (4.3)

9/450 (2.0)

2.35 (1.00–5.49)

0.050

 10–15 days

1/120 (0.8)

2/132 (1.5)

3.39 (0.30–38.69)

0.326

 16–35 days

1/41 (2.4)

1/37 (2.7)

0.57 (0.03–9.75)

0.696

 > 35 days

0/4 (0.0)

0/2 (0.0)

–

–

Duration of surgery

 ≤ 45 min

0/40 (0.0)

0/32 (0.0)

–

–

–

25/1029 (2.4)

17/1092 (1.6)

1.75 (0.93–3.29)

0.082

Surgery and impairment of renal function

 Major orthopedic surgery and moderate

2/43 (4.7)

0/48 (0.0)

–

< 0.001

 Other trauma surgery and moderate

3/25 (12.0)

0/13 (0.0)

–

< 0.001

  1. aMajor orthopedic surgery: hip replacement, knee replacement and hip fracture; Other trauma surgery: upper limb surgery and other trauma surgery. bHip and knee replacement: hip replacement and knee replacement; Trauma surgery: hip fracture; upper limb surgery and other trauma surgery. IPTW inverse-probability-of-treatment weighting method, FPX fondaparinux sodium, LMWH low molecular weight heparins, OR odds ratio
Back to article page

BMC Surgery

ISSN: 1471-2482

Contact us