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Table 3 Factors affecting recurrence-to-death survival (RTDS)

From: The impact of tumor burden at the initial hepatectomy on the recurrence-to-death survival after repeat surgical resection/radiofrequency ablation: a retrospective study

 

Univariate analysis

Multivariate analysis

Variable

p value

HR

95% CI

p value

HR

95% CI

At initial hepatectomy

      

 Age (years old)

0.355

     

 Gender(male/female)

0.449

     

 Positive HBsAg

0.129

     

 Positive HBeAg

0.402

     

 HBV-DNA

0.037

1.642

1.030–2.620

   

 Beyond Milan criteria

0.098

1.467

0.932–2.310

   

 Tumor size (cm)

0.068

1.056

0.996–1.119

   

 Tumor number

0.784

     

 Differentiation(poor/moderate-well)

0.406

     

 Microvascular invasion

0.015

1.787

1.117–2.860

   

 Satellite lesions

0.390

     

 Liver cirrhosis

0.676

     

 AFP(> 400 ng/ml)

0.595

     

 Recurrence time

0.003

0.975

0.959–0.991

0.009

0.978

0.962–0.995

 Treatments after recurrence

0.977

0.994

0.664–1.488

   

At recurrence time

      

 Tumor size (cm)

0.002

1.130

1.046–1.222

0.001

1.149

1.062–1.242

 Tumor number

0.016

1.426

1.067–1.905

   

 Satellite lesions

0.474

     

 Macrovascular invasion

0.003

3.367

1.529–7.415

   

 Extrahepatic metastasis

0.016

2.363

1.174–4.758

   

 AFP(> 400 ng/ml)

 < 0.001

2.706

1.652–4.433

 < 0.001

2.465

1.486–4.089

 TBIL(µmol/L)

0.444

     

 ALT(U/L)

0.660

     

 AST(U/L)

0.728

     

 Albumin(g/L)

0.871

     

 PLR

0.016

1.005

1.001–1.009

   

 NLR

0.692

     
  1. HBsAg hepatitis B surface antigen, HBV hepatis B viral, AFP alpha fetoprotein, TBIL total bilirubin, ALT aminotransferase, AST aspartate transaminase, ALB albumin, PLR platelets-to-lymphocyte ratio, NLR neutrophil-to-Lymphocyte Ratio