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Table 2 Hypercoagulable states and additional risk factors

From: The prognostic role of extended preoperative hypercoagulability work-up in high-risk microsurgical free flaps: a single-center retrospective case series of patients with heterozygotic factor V Leiden thrombophilia

Flap#

Patient#

Type

Location

Anamnesis

Risk factors

Hypercoagulability

1A

1.1

DIEP right

Trunk

PAE

CRT

hFVL

2A

1.2

DIEP left

Trunk

PAE

CRT

hFVL

3A

2.1

DIEP

Trunk

DVT

Hormone therapy

hFVL, hPT, F VIII ↑

4A

3.1

LD/PSC

UE

DVT

hFVL, hPT

5A

4.1

VRAM

LE

DVT

Smoking

hFVL, hPT, F VIII ↑, Protein C/S ↓

6A

5.1

DIEP

Trunk

DVT

CRT

hFVL

7A

6.1

ALT

LE

PAE

hFVL, F VIII ↓, Protein S ↓

8A

7.1

Gracilis

LE

PAE

Smoking

hFVL, hPT, F VIII ↑, Lupusinhibitor

9A

7.2

LD

LE

PAE

Smoking

hFVL, hPT, F VIII ↑, Lupusinhibitor

10A

7.3

VRAM

LE

PAE

Smoking

hFVL, hPT, F VIII ↑, Lupusinhibitor

11A

8.1

DIEP

Trunk

Miscarriage

CRT

hFVL, Protein C ↓

12A

9.3

LD

LE

Smoking

hFVL, hPT, F VIII ↑, F IX ↑, F XI ↑

13A

14.2

LD

LE

hFVL, hPT, F VIII ↑,

14A

15.2

LD

LE

-

hFVL, hPT, F VIII ↑,

1B

9.1

LD

LE

Smoking

hFVL, hPT, F VIII ↑, F IX ↑, F XI ↑

2B

9.2

Gracilis

LE

Smoking

hFVL, hPT, F VIII ↑, F IX ↑, F XI ↑

3B

10.1

LD

LE

hFVL, hPT

4B

11.1

ALT

LE

Smoking

hFVL, hPT

5B

12.1

PSC

LE

Smoking

hFVL, hPT

6B

13.1

DIEP right

Trunk

CRT/Smoking

hFVL, F VIII ↓, Protein S ↓

7B

13.2

DIEP left

Trunk

CRT/Smoking

hFVL, F VIII ↓, Protein S ↓

8B

14.1

ALT

LE

hFVL, hPT, F VIII ↑,

9B

15.1

LD

LE

Smoking

hFVL, hPT, F VIII ↑,

  1. A = Group A: hFVL diagnosis prior to free flap surgery
  2. B = Group B: hFVL diagnosis after free flap surgery
  3. ALT Anterior lateral thigh flap, CRT Chemoradiotherapy, DIEP Deep Inferior Epigastric Flap, DVT deep vein thrombosis, F female, hFVL heterozygotic factor V Leiden, hPT heterozygotic prothrombin mutation, PAE pulmonary artery embolism, PSC parascapular flap; VRAM = Vertical Rectus Abdominis Muscle