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Table 3 Clinicopathological characteristics of pN1 patients based on CLNs and LLNs

From: Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma

Clinicopathological characteristics

Total

n = 694

CLNs ≤ 5

n = 535

CLNs > 5

n = 159

P value

LLNs ≤ 5

n = 624

LLNs > 5

n = 70

P value

Age (years)

       

 Mean

 

44.0

34.0

 < 0.001*

42.0

37.5

0.040*

  < 55

585

439/535 (82.1)

146/159 (91.8)

0.003*

523/624 (83.8)

62/70 (88.6)

0.300

  ≥ 55

109

96/535 (17.9)

13/159 (8.2)

83/624 (17.6)

26/222 (11.7)

Sex

   

0.053

  

0.314

 Female

492

389/535 (72.7)

103/159 (64.8)

446/624 (71.5)

46/70 (65.7)

 Male

202

146/535 (27.3)

56/159 (35.2)

178/624 (28.5)

24/70 (34.3)

Tumor size (mm)

       

 Mean

 

10.0

14.0

 < 0.001*

11.0

15.0

 < 0.001*

  ≤ 10

329

276/535 (51.6)

53/159 (33.3)

 < 0.001*

304/624 (48.7)

25/70 (35.7)

0.001*

  10–20

267

201/535 (37.6)

66/159 (41.5)

242/624 (38.8)

25/70 (35.7)

  20–40

83

48/535 (9.0)

35/159 (22.0)

67/624 (10.7)

16/70 (22.9)

  > 40

15

10/535 (1.9)

5/159 (3.1)

11/624 (1.8)

4/70 (5.7)

Bilaterality

   

 < 0.001*

  

 < 0.001*

 Present

252

173/535 (32.3)

79/159 (49.7)

211/624 (33.8)

41/70 (58.6)

 Absent

442

362/535 (67.7)

80/159 (50.3)

423/624 (66.2)

29/70 (41.4)

Multifocality

   

0.001*

  

 < 0.001*

 Present

305

216/535 (40.4)

89/159 (56.0)

264/624 (42.3)

41/70 (58.6)

 Absent

389

319/535 (59.6)

70/159 (44.0)

360/624 (57.7)

29/70 (41.4)

CLNs

   

−

  

 < 0.001*

 ≤ 5

535

–

–

511/624 (81.9)

24/70 (34.3)

 > 5

159

–

–

113/624 (18.1)

46/70 (65.7)

ETE

   

 < 0.001*

  

 < 0.001*

 Present

565

418/535 (78.1)

147/159 (92.5)

497/624 (79.6)

68/70 (97.1)

 Absent

129

117/535 (21.9)

12/70 (7.5)

127/624 (20.4)

2/70 (2.9)

TNM stage

   

0.001*

  

0.314

 I

586

439/535 (82.1)

147/159 (92.5)

524/624 (84.0)

62/70 (88.6)

 II

108

96/535 (17.9)

12/159 (7.5)

100/624 (16.0)

8/70 (11.4)

HT

   

0.509

  

0.686

 Present

98

73/535 (13.6)

25/159 (15.7)

87/624 (13.9)

11/70 (15.7)

 Absent

596

462/535 (86.4)

134/159 (84.3)

537/624 (86.1)

59/70 (84.3)

BRAF V600E mutation

   

0.234

  

0.479

 Positive

68

52/63 (82.5)

16/23 (69.6)

58/72 (80.6)

10/14 (71.4)

 Negative

18

11/63 (17.5)

7/23 (30.4)

14/72 (19.4)

4/14 (28.6)

  1. CLNs number of central cervical lymph nodes, LLNs number of lateral lymph nodes, ETE extrathyroidal extension, TNM stage tumor node metastasis stage, HT Hashimoto’s thyroiditis
  2. *Statistically significant difference
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