Table 3 Uni- and multivariate analyses of disease-free survival (DFS) and overall survival (OS)
Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
DFS | ||||
Location, left vs right | 1.271 (1.018–1.588) | 0.034 | 1.263 (1.005–1.587) | 0.046 |
Differentiation, well vs poor | 0.712 (0.575–0.882) | 0.002 | ||
Lymphatic metastasis, yes vs no | 6.729 (2.487–18.210) | < 0.001 | 6.229 (2.228–17.412) | < 0.001 |
MVI, yes vs no | 2.390 (1.930–2.960) | < 0.001 | 1.711 (1.330–2.202) | < 0.001 |
Satellite nodule, yes vs no | 2.504 (1.875–3.345) | < 0.001 | 1.449 (1.018–2.063) | 0.040 |
GVI, yes vs no | 3.155 (2.299–4.329) | < 0.001 | ||
BCLC, A vs 0 | 1.691 (1.325–2.159) | < 0.001 | ||
BCLC, B vs 0 | 1.979 (1.371–2.856) | < 0.001 | ||
BCLC, C vs 0 | 2.897 (1.325–5.806) | < 0.001 | ||
HbeAg, positive vs negative | 1.481 (1.155–1.899) | 0.002 | 1.639 (1.255–2.139) | < 0.001 |
AFP, > 400 vs < = 400 ng/mL | 1.762 (1.425–2.180) | < 0.001 | 1.421 (1.131–1.786) | 0.003 |
Age, y (continuous) | 0.984 (0.975–0.993) | < 0.001 | ||
Tumor diameter, cm (continuous) | 1.092 (1.066–1.119) | < 0.001 | ||
NEU, 109/L (continuous) | 1.078 (1.000–1.162) | 0.049 | ||
Platelet, 109/L (continuous) | 1.003 (1.001–1.005) | < 0.001 | ||
AST, U/L (continuous) | 1.004 (1.002–1.006) | < 0.001 | ||
Long-term OS | ||||
Location, left vs right | 4.793 (2.132–10.780) | < 0.001 | 3.232 (1.284–8.134) | 0.013 |
MVI, yes vs no | 4.117 (1.897–8.935) | < 0.001 | 3.161 (1.284–7.786) | 0.012 |
Satellite nodule, yes vs no | 3.017 (1.029–8.845) | 0.044 | ||
GVI, yes vs no | 4.215 (1.566–11.340) | 0.004 | ||
BCLC, C vs 0 | 4.831 (1.696–13.765) | 0.003 | ||
AFP, > 400 vs ≤ 400 ng/mL | 2.230 (1.016–4.891) | 0.046 | ||