Table 6 Univariate and multivariate analysis to identify factors that predict recurrence-free survival in patients with ruptured hepatocellular carcinoma treated by hepatectomy

From: The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy

	Univariate analysis			Multivariate analysis
	p	HR	95%confidence interval	p	HR	95%confidence interval
Gender
Male/female	0.872	1.044	0.648–1.883
Age
Per year	0.470	0.994	0.983–1.013
Tumor length
Per cm	0.001	1.981	1.096–2.779	0.001	1.932	1.295–2.881
Tumor number
Mutiple/single	0.171	1.460	0.783–2.370
BCLC	0.118
B/A	0.526	1.193	0.598–1.890
C/A	0.039	1.594	0.927–2.254
Child–Pugh
B/A	0.169	0.717	0.450–1.163
AFP
> 400 ng/ml/ ≤ 400 ng/ml	0.112	1.312	0.812–1.823
Edmondson-steiner
IV/III/II/I	0.323	1.099	0.830–1.204
Necrosis
Yes/no	0.443	0.854	0.513–1.175
Local invasion
Yes/no	0.078	1.363	0.929–1.864
ALB
Per g	0.312	0.982	0.944–1.017
ALT
Per U	0.165	0.995	0.989–1.002
AST
Per U	0.224	1.002	0.998–1.006
ALP
Per U	0.965	1.000	0.998–1.002
GGT
Per U	0.001	1.004	1.002–1.006	< 0.001	1.003	1.002–1.005
HBsAg
Yes/no	0.468	0.826	0.408–1.162
Times of HIO	0.001			< 0.001
1/0	0.007	1.659	1.158–2.405	0.003	1.643	1.181–2.285
2/0	0.001	2.604	1.505–4.491	< 0.001	2.501	1.521–4.112
Blood loss
> 400 ml/ ≤ 400 ml	0.003	1.454	1.092–1.626	0.082	1.276	0.926–1.427

BCLC, Barcelona Clinic Liver Cancer; AFP, alpha fetoprotein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; HIO, hepatic inflow occlusion

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