BMC Surgery

Table 5 Univariate and multivariate analysis to identify factors that predict overall survival in patients with ruptured hepatocellular carcinoma treated by hepatectomy

From: The effect of the number of hepatic inflow occlusion times on the prognosis of ruptured hepatocellular carcinoma patients after hepatectomy

	Univariate analysis			Multivariate analysis
	p	HR	95%confidence interval	p	HR	95%confidence interval
Gender
Male/female	0.427	1.234	0.735–2.070
Age
Per year	0.720	1.003	0.987–1.019
Tumor length
Per cm	0.041	1.636	1.020–2.626	0.013	1.691	1.119–2.554
Tumor number
Mutiple/single	0.021	1.822	1.095–3.034	0.016	1.862	1.120–3.096
BCLC	0.010			0.003
B/A	0.621	0.873	0.509–1.496	0.822	0.941	0.552–1.603
C/A	0.002	2.000	1.296–3.087	0.003	1.880	1.239–2.852
Child–Pugh
B/A	0.082	0.665	0.420–1.053
AFP
> 400 ng/ml/ ≤ 400 ng/ml	0.071	1.452	0.969–2.175
Edmondson-steiner
IV/III/II/I	0.637	1.046	0.969–2.175
Necrosis
Yes/no	0.485	0.872	0.867–1.263
Local invasion
Yes/no	0.002	1.718	0.592–1.282	0.001	1.686	1.223–2.323
ALB
Per g	0.005	0.957	1.226–2.407	0.014	0.969	0.945–0.994
ALT
Per U	0.007	0.990	0.927–0.987	< 0.001	0.987	0.980–0.994
AST
Per U	0.010	1.006	0.982–0.997	0.001	1.007	1.003–1.011
ALP
Per U	0.024	1.002	1.001–1.010	0.030	1.002	1.000–1.003
GGT
Per U	0.775	1.000	0.998–1.002
HBsAg
Yes/no	0.242	0.736	0.440–1.230
Times of HIO	< 0.001			< 0.001
1/0	0.298	1.215	0.842–1.752	0.495	1.130	0.795–1.606
2/0	< 0.001	4.522	2.542–8.045	< 0.001	4.116	2.398–7.065
Blood loss
> 400 ml/ ≤ 400 ml	0.023	1.322	1.182–1.744	0.144	1.288	0.892–1.286

BCLC, Barcelona Clinic Liver Cancer; AFP, alpha fetoprotein; ALB, albumin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; HIO, hepatic inflow occlusion

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