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Table 3 Comparison of the hematological markers between groups at the baseline and end of the study

From: The effects of preoperative supplementation with a combination of beta‐hydroxy‐beta‐methylbutyrate, arginine, and glutamine on inflammatory and hematological markers of patients with heart surgery: a randomized controlled trial

Variablea

Heallagen (n = 30)

Placebo (n = 30)

Pb

P-adjusted 1c

Neutrophil (%)

Baseline

63.62 ± 7.28

65.4 ± 11.17

0.469

0.682

 

End of the study

82.95 ± 9.29

79.62 ± 9.04

0.165

0.138

 

Changes

19.32 ± 10.20

14.22 ± 13.83

0.035*

0.033¥

 

Pd

 < 0.001

 < 0.001

  

Lymphocyte (%)

Baseline

30.51 ± 8.08

29.49 ± 10.53

0.677

0.811

End of the study

11.54 ± 8.06

21.70 ± 20.69

0.007**

0.006**

Changes

− 18.97 ± 9.68

− 7.79 ± 26.39

0.080*

0.085¥

Pd

 < 0.001

0.117

  

Platelet (103/mm3)

Baseline

187.16 ± 41.90

196.43 ± 53.22

0.480**

0.770¥

End of the study

164.46 ± 52.73

158.83 ± 29.64

0.410*

0.909¥

Changes

− 22.70 ± 65.68

-37.60 ± 47.45

0.988*

0.949¥

Pd

0.057*

 < 0.001*

  

RBC (cells/mm3)

Baseline

4.85 ± 0.62

4.64 ± 0.65

0.536

0.702

End of the study

3.67 ± 0.90

3.54 ± 0.73

0.728*

0.749¥

Changes

− 1.17 ± 1.04

− 1.09 ± 0.84

0.765

0.812

Pd

 < 0.001*

 < 0.001*

  

WBC (cells/mm3)

Baseline

6746.66 ± 1361.47

6834.00 ± 1903.15

0.839

0.714

End of the study

11,421.33 ± 4760.87

10,122.16 ± 4124.20

0.459*

0.772¥

Changes

4674.66 ± 4330.44

3288.16 ± 3817.91

0.379*

0.611¥

Pd

 < 0.001*

 < 0.001*

  

BUN (mmol/L)

Baseline

16.83 ± 5.38

14.77 ± 4.29

0.107

0.112

End of the study

16.59 ± 5.16

14.29 ± 3.74

0.064**

0.050**

Changes

− 0.24 ± 4.88

− 0.48 ± 3.74

0.832

0.691

Pd

0.787

0.485

  

Creatinine (mmol/L)

Baseline

1.28 ± 1.28

1.01 ± 0.24

0.255*

0.633¥

End of the study

1.23 ± 1.31

1.44 ± 1.06

0.089*

0.091¥

Changes

− 0.04 ± 0.28

0.43 ± 1.13

0.054*

0.208¥

Pd

0.402*

0.060*

  
  1. RBC red blood cells, WBC white blood cells, BUN blood urea nitrogen
  2. aData are presented as mean (SD)
  3. bCalculated using independent sample t-test (variables that entered as logarithm form are indicated by **) or Mann–Whitney U-test (indicated by *)
  4. cCalculated using ANCOVA (variables that entered as logarithm form are indicated by **) or non-parametric ranked ANCOVA (indicated by ¥), adjusted for the effect of BMI, age, -gender and history of HTN
  5. dCalculated using paired t-test or Wilcoxon rank test (indicated by *)